MMN/P3a deficits in first episode psychosis: Comparing schizophrenia-spectrum and affective-spectrum subgroups

M Kaur; R A Battisti; P B Ward; A Ahmed; I B Hickie; Daniel F Hermens

doi:10.1016/j.schres.2011.03.025

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MMN/P3a deficits in first episode psychosis: Comparing schizophrenia-spectrum and affective-spectrum subgroups

Journal article

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MMN/P3a deficits in first episode psychosis: Comparing schizophrenia-spectrum and affective-spectrum subgroups

M Kaur, R A Battisti, P B Ward, A Ahmed, I B Hickie and Daniel F Hermens

Schizophrenia Research, Vol.130(1-3), pp.203-209

2011

DOI: https://doi.org/10.1016/j.schres.2011.03.025

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Abstract

First-episode

schizophrenia

affective

mismatch negativity

cognition

psychosocial

Background: Reduced mismatch negativity (MMN) and P3a amplitudes are neurophysiological biomarkers for schizophrenia that index deviance detection and the orienting response, respectively. First-episode psychosis (FEP) patients show reduced amplitudes of the 'MMN/P3a complex', but it is unclear whether this occurs across the FEP spectrum. Methods: Fifty-three young people (17-36. years) were assessed: 17 FEP affective-spectrum (bipolar disorder with psychotic features and major depressive disorder with psychotic features), 18 FEP schizophrenia-spectrum (schizophrenia, schizoaffective disorder, and schizophreniform disorder), and 18 healthy controls. MMN/P3a was acquired during a two-tone, auditory paradigm with 8% duration deviants. Clinical, psychosocial and neuropsychological assessments were also undertaken. Results: FEP schizophrenia- and FEP affective-spectrum showed significantly reduced fronto-central MMN and central P3a amplitudes compared to controls. FEP subgroups also showed significantly poorer cognitive and psychosocial functioning. The combined FEP sample showed significant correlations between fronto-central MMN amplitudes and cognitive measures. Discussion: FEP schizophrenia-spectrum and FEP affective-spectrum were similarly impaired in two biomarkers for schizophrenia. FEP subgroups showed impairments in fronto-central MMN consistent with chronic patients. Similarly, both subgroups showed reductions in P3a; although the affective subgroup showed an 'intermediate' frontal response. These findings suggest that FEP patients with both affective and schizophrenia spectrum diagnoses share common neurobiological disturbances in deviance detection/orienting processes in the early phase of illness. © 2011 Elsevier B.V.

Details

Title: MMN/P3a deficits in first episode psychosis: Comparing schizophrenia-spectrum and affective-spectrum subgroups
Authors: M Kaur (Author) - University of Sydney
R A Battisti (Author) - University of Sydney
P B Ward (Author) - University of New South Wales
A Ahmed (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
Publication details: Schizophrenia Research, Vol.130(1-3), pp.203-209
Publisher: Elsevier BV
Date published: 2011
DOI: 10.1016/j.schres.2011.03.025
ISSN: 0920-9964
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450545402621
Output Type: Journal article

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