Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression

Rebecca Robillard; Jim Lagopoulos; Daniel F Hermens; Sharon L Naismith; Naomi L Rogers; Django White; Joanne S Carpenter; Manreena Kaur; Elizabeth M Scott; Ian B Hickie

doi:10.3389/fnins.2017.00336

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Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression

Journal article

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Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression

Rebecca Robillard, Jim Lagopoulos, Daniel F Hermens, Sharon L Naismith, Naomi L Rogers, Django White, Joanne S Carpenter, Manreena Kaur, Elizabeth M Scott and Ian B Hickie

Frontiers in Neuroscience, Vol.11, 336

2017

DOI: https://doi.org/10.3389/fnins.2017.00336

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

melatonin

depression

magnetic resonance spectroscopy

myo-inositol

circadian

UniSC Diversity Area - Life Stages

Myo-inositol, a second messenger glucose isomer and glial marker, is potentiated by melatonin. In addition to common abnormalities in melatonin regulation, depressive disorders have been associated with reduced myo-inositol in frontal structures. This study examined associations between myo-inositol in the anterior cingulate cortex and the timing of evening melatonin release. Forty young persons with unipolar depression were recruited from specialized mental health services (20.3±3.8 years old). Healthy controls were recruited from the community (21.7±2.6 years old). The timing of dim light melatonin onset (DLMO) was estimated using salivary melatonin sampling. Myo-inositol concentrations (MI/CrPCr ratio) in the anterior cingulate cortex were obtained using proton magnetic resonance spectroscopy. After controlling for age, sex, and CrPCr concentration the depression group had significantly lower MI/CrPCr ratios than healthy controls [F(4, 75) = 11.4, p = 0.001]. In the depression group, later DLMO correlated with lower MI/CrPCr ratio (r = -0.48, p = 0.014). These findings suggest that neurochemical changes in the frontal cortex are associated with circadian disruptions in young persons with depression.

Details

Title: Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression
Authors: Rebecca Robillard (Author) - Institute of Mental Health Research, Canada
Jim Lagopoulos (Author) - University of the Sunshine Coast - Faculty of Arts, Business and Law
Daniel F Hermens (Author) - University of Sydney
Sharon L Naismith (Author) - University of Sydney
Naomi L Rogers (Author) - University of Sydney
Django White (Author) - University of Sydney
Joanne S Carpenter (Author) - University of Sydney
Manreena Kaur (Author) - University of Sydney
Elizabeth M Scott (Author) - University of Sydney
Ian B Hickie (Author) - University of Sydney
Publication details: Frontiers in Neuroscience, Vol.11, 336; 6
Publisher: Frontiers Research Foundation
Date published: 2017
DOI: 10.3389/fnins.2017.00336
ISSN: 1662-4548
Copyright note: Copyright © 2017 Robillard, Lagopoulos, Hermens, Naismith, Rogers, White, Carpenter, Kaur, Scott and Hickie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451286902621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences

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