Journal article
Low serum selenium in pregnancy is associated with reduced T-3 and increased risk of GDM
Journal of Endocrinology, Vol.248(1), pp.45-57
2021
PMID: 33112790
Abstract
Thyroid disorders are the most common endocrine disorders affecting women commencing pregnancy. Thyroid hormone metabolism is strongly influenced by selenium status; however, the relationship between serum selenium concentrations and thyroid hormones in euthyroid pregnant women is unknown. This study investigated the relationship between maternal selenium and thyroid hormone status during pregnancy by utilizing data from a retrospective, cross-sectional study (Maternal Outcomes and Nutrition Tool or MONT study) with cohorts from two tertiary care hospitals in South East Queensland, Australia. Pregnant women (n = 206) were recruited at 26-30 weeks gestation and serum selenium concentrations were assessed using inductively coupled plasma mass spectrometry. Thyroid function parameters were measured in serum samples from women with the lowest serum selenium concentrations (51.2 +/- 1.2 mu g/L), women with mean concentrations representative of the entire cohort (78.8 +/- 0.4 mu g/L) and women with optimal serum selenium concentrations (106.9 +/- 2.3 mu g/L). Women with low serum selenium concentrations demonstrated reduced fT(3) levels (P < 0.05) and increased TPOAb (P < 0.01). Serum selenium was positively correlated with fT(3) (P < 0.05) and negatively correlated with TPOAb (P < 0.001). Serum fT(4) and thyroid-stimulating hormone (TSH) were not different between all groups, though the fT(4)/TSH ratio was increased in the low selenium cohort (P < 0.05). Incidence of pregnancy disorders, most notably gestational diabetes mellitus, was increased within the low serum selenium cohort (P < 0.01). These results suggest selenium status in pregnant women of South East Queensland may not be adequate, with possible implications for atypical thyroid function and undesirable pregnancy outcomes.
Details
- Title
- Low serum selenium in pregnancy is associated with reduced T-3 and increased risk of GDM
- Authors
- Pierre Hofstee (Author) - Griffith UniversityJanelle James-McAlpine (Author) - Griffith UniversityDaniel R. McKeating (Author) - Griffith UniversityJessica J. Vanderlelie (Author) - La Trobe UniversityJames S. M. Cuffe (Author) - University of QueenslandAnthony Perkins (Corresponding Author) - Griffith University
- Publication details
- Journal of Endocrinology, Vol.248(1), pp.45-57
- Publisher
- BioScientifica Ltd.
- DOI
- 10.1530/JOE-20-0319
- ISSN
- 1479-6805
- PMID
- 33112790
- Grant note
- RPCPHD0192017 / Queensland Health Children's Hospital Foundation
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
- Language
- English
- Record Identifier
- 99685298802621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Endocrinology & Metabolism
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Source: InCites