Low mannose-binding lectin function is associated with sepsis in adult patients

Damon P Eisen; Melinda M Dean; Peter Thomas; Penny Marshall; Natalie Gerns; Sue Heatley; Josephine Quinn; Robyn M Minchinton; Jeff Lipman

doi:10.1111/j.1574-695X.2006.00144.x

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Low mannose-binding lectin function is associated with sepsis in adult patients

Journal article

Peer reviewed

Low mannose-binding lectin function is associated with sepsis in adult patients

Damon P Eisen, Melinda M Dean, Peter Thomas, Penny Marshall, Natalie Gerns, Sue Heatley, Josephine Quinn, Robyn M Minchinton and Jeff Lipman

FEMS Immunology and Medical Microbiology, Vol.48(2), pp.274-282

2006

DOI: https://doi.org/10.1111/j.1574-695X.2006.00144.x

PMID: 17064281

Abstract

innate immunity

deficiency

mannose-binding lectin

sepsis

Mannose-binding lectin (MBL) is an innate immune system pattern recognition molecule that kills a wide range of pathogens via the lectin complement pathway. MBL deficiency is associated with severe infection but the best measure of this deficiency is undecided. We investigated the influence of MBL functional deficiency on the development of sepsis in 195 adult patients, 166 of whom had bloodstream infection and 35 had pneumonia. Results were compared with 236 blood donor controls. MBL function (C4b deposition) and levels were measured by enzyme-linked immunosorbent assay. Using receiver operator characteristics of MBL function in healthy controls, we identified a level of <0.2 U µL−1 as a highly discriminative marker of low MBL2 genotypes. Median MBL function was lower in sepsis patients (0.18 U µL−1) than in controls (0.48 U µL−1, P<0.001). MBL functional deficiency was more common in sepsis patients than controls (P<0.001). MBL functional deficient patients had significantly higher sequential organ failure assessment (SOFA) scores and higher MBL function and levels were found in patients with SOFA scores predictive of good outcome. Deficiency of MBL function appears to be associated with bloodstream infection and the development of septic shock. High MBL levels may be protective against severe sepsis.

Details

Title: Low mannose-binding lectin function is associated with sepsis in adult patients
Authors: Damon P Eisen - Royal Melbourne Hospital
Melinda M Dean - Australian Red Cross Blood Service
Peter Thomas - Royal Brisbane and Women's Hospital
Penny Marshall - Royal Brisbane and Women's Hospital
Natalie Gerns - Royal Brisbane and Women's Hospital
Sue Heatley - Australian Red Cross Blood Service
Josephine Quinn - Royal Brisbane and Women's Hospital
Robyn M Minchinton - Australian Red Cross Blood Service
Jeff Lipman - Royal Brisbane and Women's Hospital
Publication details: FEMS Immunology and Medical Microbiology, Vol.48(2), pp.274-282
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2006
DOI: 10.1111/j.1574-695X.2006.00144.x
ISSN: 1574-695X
PMID: 17064281
Organisation Unit: School of Health - Biomedicine
Language: English
Record Identifier: 991037798302621
Output Type: Journal article