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Diabetic Medicine - 2023 - James - Low‐density lipoprotein cholesterol in adolescents and young adults with type 1 diabetes163.42 kB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Low-density lipoprotein cholesterol in adolescents and young adults with type 1 diabetes: Data from the Australasian Diabetes data network (Addn) registry
Diabetic Medicine, Vol.40(11), pp.1-8
2023
Abstract
Aim: To determine low-density lipoprotein cholesterol (LDL-C) screening frequency and levels, and factors associated with elevated LDL-C, in Australasian youth with type 1 diabetes (T1D).
Methods: Data were extracted from the Australasian Diabetes Data Network (ADDN), a prospective clinical quality registry, on all T1D healthcare visits attended by young people aged 16-25 years (with T1D duration of >1 year) between January 2011-December 2020. The primary outcomes were elevated LDL-C >2.6 mmol/L (100 mg/dL) and threshold for treatment: >3.4 mmol/L (130 mg/dL), according to consensus guidelines. Multivariable Generalised Estimated Equations (GEE) were used to examine factors associated with elevated LDL-C across all visits.
Results: A cohort of 6338 young people (52.6% male) were identified, of whom 1603 (25.3%) had ≥1 LDL-C measurement documented. At last measurement, mean age, age at T1D diagnosis and T1D duration were 18.3±2.4, 8.8±4.5 and 8.9±4.8 years, respectively. LDL-C was elevated in 737 (46.0%) and at the treatment threshold in 250 (15.6%). In multivariable GEE elevated LDL-C continuously was associated with older age (OR=0.07; 0.01 to 0.13, p=0.02), female sex (OR=0.31; 0.18 to 0.43; p<0.001), higher HbA1c (OR=0.04; 0.01 to 0.08; p=0.01), and having an elevated BMI (OR=0.17, 0.06 to 0.39, p<0.001).
Conclusions: LDL-C screening and levels are suboptimal in this cohort, increasing future cardiovascular complication risk. There is an urgent need to understand how healthcare services can support improved screening and management of dyslipidaemia in this population.
Details
- Title
- Low-density lipoprotein cholesterol in adolescents and young adults with type 1 diabetes: Data from the Australasian Diabetes data network (Addn) registry
- Authors
- Steven James (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - NursingKim Donaghue (Author) - Children's Hospital at WestmeadAllison L Perry (Author) - University of Technology SydneyJ Lowe (Author) - University of TorontoP Colman (Author) - The Royal Melbourne HospitalM Craig (Author) - The University of Sydney
- Publication details
- Diabetic Medicine, Vol.40(11), pp.1-8
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2023
- DOI
- 10.1111/dme.15184
- ISSN
- 1464-5491; 0742-3071
- Copyright note
- © 2023 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Grant note
- APP1136735 / National Health and Medical Research (Australia) practitioner fellowship
- Organisation Unit
- School of Health - Nursing
- Language
- English
- Record Identifier
- 99741796002621
- Output Type
- Journal article
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