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Published VersionCC BY V4.0, Open Access
Journal article
Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes
PLoS One, Vol.12(6), pp.1-22
2017
PMCID: PMC5491256
PMID: 28662138
Abstract
Knowledge of the normal in vivo thickness of the retina, and its individual layers in pediatric populations is important for diagnosing and monitoring retinal disorders, and for understanding the eye's normal development and the impact of eye growth and refractive error such as myopia (short-sightedness) upon retinal morphology. In this prospective, observational longitudinal study, total retinal thickness (and individual retinal layer thickness) and the changes in retinal morphology occurring over an 18-month period were examined in 101 children with a range of refractive errors. In childhood, the presence of myopia was associated with subtle but statistically significant (p<0.05) changes in the topographical thickness distribution of macular retinal thickness (and retinal layer thickness), characterised by a thinning of the parafoveal retina (and parafoveal or perifoveal thinning in most outer and inner retinal layers). The parafoveal retina was on average 6 pm thinner in myopic children. However, over 18 months, longitudinal changes in retinal thickness and individual layers were of small magnitude (average changes of less than 2 pm over 18 months), indicative of a high degree of stability in retinal morphology in healthy adolescent eyes, despite significant eye growth over this same period of time. This provides the first detailed longitudinal assessment of macula retinal layer morphology in adolescence, and delivers new normative data on expected changes in retinal structure over time and associated with myopia during this period of childhood development.
Details
- Title
- Longitudinal changes in macular retinal layer thickness in pediatric populations: Myopic vs non-myopic eyes
- Authors
- Scott A. Read (Corresponding Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyStephen J. Vincent (Author) - Queensland University of Technology
- Publication details
- PLoS One, Vol.12(6), pp.1-22
- Publisher
- Public Library of Science
- Date published
- 2017
- DOI
- 10.1371/journal.pone.0180462
- ISSN
- 1932-6203
- PMID
- 28662138; PMC5491256
- Copyright note
- © 2017 Read et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Data Availability
- All relevant data are within the paper and its Supporting Information files.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973597102621
- Output Type
- Journal article
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- Web Of Science research areas
- Ophthalmology
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