Journal article
Longitudinal associations between resting-state, interregional theta-beta phase-amplitude coupling, psychological distress, and wellbeing in 12-15-year-old adolescents
Cerebral Cortex , Vol.33(12), pp.8066-8074
2023
PMID: 37005062
Appears in Thompson Institute Research Collection
Abstract
Cross-frequency coupling between the phase of slower oscillatory activity and the amplitude of faster oscillatory activity in the brain (phase-amplitude coupling; PAC), is a promising new biological marker for mental health. Prior research has demonstrated that PAC is associated with mental health. However, most research has focused on within-region theta-gamma PAC in adults. Our recent preliminary study found increased theta-beta PAC was associated with increased psychological distress in 12 year olds. It is important to investigate how PAC biomarkers relate to mental health and wellbeing in youth. Thus, in this study, we investigated longitudinal associations between interregional (posterior-anterior cortex) resting-state theta-beta PAC (Modulation Index [MI]), psychological distress and wellbeing in N = 99 adolescents (aged 12-15 years). In the right hemisphere, there was a significant relationship, whereby increased psychological distress was associated with decreased theta-beta PAC and psychological distress increased with increased age. In the left hemisphere, there was a significant relationship, whereby decreased wellbeing was associated with decreased theta-beta PAC and wellbeing scores decreased with increased age. This study presents novel findings demonstrating longitudinal relationships between interregional, resting-state theta-beta PAC and mental health and wellbeing in early adolescents. This EEG marker may facilitate improved early identification of emerging psychopathology.
Details
- Title
- Longitudinal associations between resting-state, interregional theta-beta phase-amplitude coupling, psychological distress, and wellbeing in 12-15-year-old adolescents
- Authors
- Dashiell D Sacks (Corresponding Author) - University of the Sunshine Coast, Queensland, Thompson InstitutePaul E Schwenn (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteAmanda Boyes (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteLia Mills (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteChristina Driver (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJustine M Gatt (Author) - UNSW AustraliaJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Cerebral Cortex , Vol.33(12), pp.8066-8074
- Publisher
- Oxford University Press
- Date published
- 2023
- DOI
- 10.1093/cercor/bhad099
- ISSN
- 1460-2199
- PMID
- 37005062
- Grant note
- DS was supported by an Australian Government Research Training Program (RTP) Scholarship. The LABS is supported by a grant from the Australian Commonwealth Government’s “Prioritising Mental Health Initiative” (2018–2019).
- Organisation Unit
- Centre for Human Factors and Systems Science; Graduate Research School; Thompson Institute
- Language
- English
- Record Identifier
- 99716088102621
- Output Type
- Journal article
Metrics
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- Collaboration types
- Domestic collaboration
- Web Of Science research areas
- Neurosciences