Journal article
Longitudinal associations between resting-state, interregional theta-beta phase-amplitude coupling and cognition in 12-15-year-old adolescents
Brain and Cognition, Vol.195, pp.1-8
2026
PMID: 41780127
Abstract
Phase-amplitude coupling (PAC) between the phase of slower oscillatory activity and the amplitude of faster oscillatory activity in the brain is believed to be a fundamental mechanism involved in information processing. We investigated longitudinal associations between interregional (posterior-anterior cortex), resting-state theta-beta PAC (Modulation Index) and cognition in N = 79 adolescents (aged 12-15 years) with repeated measures. Greater theta-beta PAC MI was associated with faster psychomotor speed, and greater attention and working memory scores, longitudinally. Greater right theta-beta PAC MI was associated with greater attention and executive functioning, longitudinally. There was no association between PAC MI and working memory or verbal learning and memory. However, in the left hemisphere there were significant associations between PAC and these cognitive variables, whereby greater working memory and greater verbal learning and memory were both associated with a lower amplitude-providing frequency. In the left hemisphere, greater attention and working memory was also associated with greater phase-providing frequency. Overall, the results support the notion that resting-state theta-beta PAC could serve as a biomarker of cognition in adolescents. Future studies investigating theta-beta PAC may help explicate the close interrelation between mental health and cognition and support the identification of cognitive impairments in mental disorders.
Details
- Title
- Longitudinal associations between resting-state, interregional theta-beta phase-amplitude coupling and cognition in 12-15-year-old adolescents
- Authors
- Dashiell D Sacks (Corresponding Author) - University of the Sunshine CoastPaul E Schwenn - University of the Sunshine CoastLia Mills - University of the Sunshine CoastKassie Bromley - University of the Sunshine CoastTaliah Prince - University of the Sunshine CoastMarcella J Parker - University of the Sunshine CoastSophie C Andrews - University of the Sunshine CoastJim Lagopoulos - University of the Sunshine CoastDaniel F Hermens (Corresponding Author) - University of the Sunshine Coast
- Publication details
- Brain and Cognition, Vol.195, pp.1-8
- Publisher
- Academic Press
- Date published
- 2026
- DOI
- 10.1016/j.bandc.2026.106419
- ISSN
- 1090-2147
- PMID
- 41780127
- Copyright note
- © 2026 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/bync/4.0/).
- Data Availability
- The data, and code necessary to reproduce the analyses presented here are available from the corresponding author upon reasonable request.
- Grant note
- The LABS is supported by a grant from the Australian Commonwealth Government's ‘Prioritising Mental Health Initiative’ (2018–19).
- Organisation Unit
- Centre for Human Factors and Systems Science; Healthy Ageing Research Cluster; Thompson Institute
- Language
- English
- Record Identifier
- 991212652402621
- Output Type
- Journal article
Metrics
1 File views/ downloads
3 Record Views