Journal article
Longitudinal Changes in Choroidal Thickness and Eye Growth in Childhood
Investigative Ophthalmology & Visual Science, Vol.56(5), pp.3103-3112
2015
PMID: 26024094
Abstract
PURPOSE. To examine longitudinal changes in choroidal thickness and axial length in a population of children with a range of refractive errors.
METHODS. One hundred and one children (41 myopes and 60 nonmyopes) aged 10 to 15 years participated in this prospective, observational longitudinal study. For each child, 6-month measures of choroidal thickness (using enhanced depth imaging optical coherence tomography) and axial ocular biometry were collected four times over an 18-month period. Linear mixed-models were used to examine the longitudinal changes in choroidal thickness and the relationship between changes in choroidal thickness and axial eye growth over the study period.
RESULTS. A significant group mean increase in subfoveal choroidal thickness was observed over 18 months (mean increase 13 +/- 22 mu m, P < 0.001). Myopic children exhibited significantly thinner choroids compared with nonmyopic children (P < 0.001), although there was no significant time by refractive group interaction (P = 0.46), indicating similar changes in choroidal thickness over time in myopes and nonmyopes. However, a significant association between the change in choroidal thickness and the change in axial length over time was found (P < 0.001, beta = -0.14). Children showing faster axial eye growth exhibited significantly less choroidal thickening over time compared with children showing slower axial eye growth.
CONCLUSIONS. A significant increase in choroidal thickness occurs over an 18-month period in normal 10- to 15-year-old children. Children undergoing faster axial eye growth exhibited less thickening and, in some cases, a thinning of the choroid. These findings support a potential role for the choroid in the mechanisms regulating eye growth in childhood.
Details
- Title
- Longitudinal Changes in Choroidal Thickness and Eye Growth in Childhood
- Authors
- Scott A. Read (Corresponding Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyStephen J. Vincent (Author) - Queensland University of TechnologyMichael J. Collins (Author) - Queensland University of Technology
- Publication details
- Investigative Ophthalmology & Visual Science, Vol.56(5), pp.3103-3112
- Publisher
- Association for Research in Vision and Ophthalmology
- Date published
- 2015
- DOI
- 10.1167/iovs.15-16446
- ISSN
- 1552-5783
- PMID
- 26024094
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973596402621
- Output Type
- Journal article
Metrics
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- Ophthalmology
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