Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia

Caroline H S Barwood; Bruce E Murdoch; Stephan Riek; John D O'Sullivan; Andrew Wong; David Lloyd; Alan Coulthard

doi:10.3233/NRE-130915

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Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia

Journal article

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Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia

Caroline H S Barwood, Bruce E Murdoch, Stephan Riek, John D O'Sullivan, Andrew Wong, David Lloyd and Alan Coulthard

NeuroRehabilitation, Vol.32(4), pp.915-928

2013

DOI: https://doi.org/10.3233/NRE-130915

PMID: 23867417

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Abstract

Aphasia - physiopathology

Double-Blind Method

Brain - physiopathology

Humans

Middle Aged

Speech Therapy

Stroke - complications

Male

Transcranial Magnetic Stimulation - methods

Recovery of Function

Aphasia - therapy

Language Tests

Aged, 80 and over

Aphasia - etiology

Brain - pathology

Female

Aged

Chronic Disease

Repetitive transcranial magnetic stimulation (rTMS) has emerged as a potential therapeutic tool for the rehabilitation of language in chronic non-fluent aphasia post-stroke. Previous studies report that low frequency (1 Hz) rTMS applied to homologous language sites can facilitate behavioural language changes. Improvements in picture naming performance and speech output are frequently reported. This study aims to assess the efficacy of inhibitory rTMS to modulate language performance in non-fluent aphasia. Low-frequency (1 Hz) rTMS was applied to six active stimulation and six placebo patients for 20 min per day over 10 days, as outlined in a previous published investigation. Behavioural language outcome measures were taken at baseline (pre-stimulation) and 1 week, 2 months, 8 months and 12 months post-stimulation. The findings demonstrate treatment-related changes observed in the stimulation group, up to 12 months post-stimulation, when compared to the placebo control group over time for naming performance, expressive language and auditory comprehension. These outcomes provide considerable evidence to support the theory of rTMS modulating mechanisms of transcallosal disinhibition in the aphasic brain, and highlight the potential clinical application of rTMS for language rehabilitation in chronic aphasia.

Details

Title: Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia
Authors: Caroline H S Barwood (Author) - University of Queensland
Bruce E Murdoch (Author) - University of Queensland
Stephan Riek (Author) - University of Queensland
John D O'Sullivan (Author) - Royal Brisbane and Women's Hospital
Andrew Wong (Author) - Royal Brisbane and Women's Hospital
David Lloyd (Author) - University of Queensland
Alan Coulthard (Author) - Royal Brisbane and Women's Hospital
Publication details: NeuroRehabilitation, Vol.32(4), pp.915-928
Publisher: IOS Press
DOI: 10.3233/NRE-130915
ISSN: 1878-6448
PMID: 23867417
Organisation Unit: University of the Sunshine Coast, Queensland; Graduate Research School
Language: English
Record Identifier: 99472604902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Clinical Neurology; Rehabilitation

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