Journal article
Long-Term Alteration in Maternal Blood Pressure and Renal Function After Pregnancy in Normal and Growth-Restricted Rats
Hypertension, Vol.60(1), pp.206-213
2012
PMID: 22585946
Abstract
Intrauterine growth restriction is associated with increased risk of adult cardiorenal diseases. Small birth weight females are more likely to experience complications during their own pregnancy, including pregnancy-induced hypertension, preeclampsia, and gestational diabetes. We determined whether the physiological demand of pregnancy predisposes growth-restricted females to cardiovascular and renal dysfunction later in life. Late gestation bilateral uterine vessel ligation was performed in Wistar-Kyoto rats. At 4 months, restricted and control female offspring were mated with normal males and delivered naturally (ex-pregnant). Regardless of maternal birth weight, at 13 months, ex-pregnant females developed elevated mean arterial pressure (indwelling tail-artery catheter; +6 mm Hg), reduced effective renal blood flow (C-14-PAH clearance; -23%), and increased renal vascular resistance (+27%) compared with age-matched virgins. Glomerular filtration rate (H-3-inulin clearance) was not different across groups. This adverse cardiorenal phenotype in ex-pregnant females was associated with elevated systemic (+57%) and altered intrarenal components of the renin-angiotensin system. After pregnancy at 13 months, coronary flow (Langendorff preparation) was halved in restricted females compared with controls, and together with reduced NO excretion, this may increase susceptibility to additional lifestyle challenges. Our results have implications for aging females who have been pregnant, suggesting long-term cardiovascular and renal alterations, with additional consequences for females who were small at birth.
Details
- Title
- Long-Term Alteration in Maternal Blood Pressure and Renal Function After Pregnancy in Normal and Growth-Restricted Rats
- Authors
- Linda A. Gallo (Author) - University of MelbourneKate M. Denton (Author) - Monash UniversityKaren M. Moritz (Author) - University of QueenslandMarianne Tare (Author) - Monash UniversityHelena C. Parkington (Author) - Monash UniversityMeagan Davies (Author) - Monash Univ, Dept Physiol, Clayton, Vic 3168, AustraliaMelanie Tran (Author) - University of MelbourneAndrew J. Jefferies (Author) - University of MelbourneMary E. Wlodek (Corresponding Author) - University of Melbourne
- Publication details
- Hypertension, Vol.60(1), pp.206-213
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/HYPERTENSIONAHA.112.195578
- ISSN
- 1524-4563
- PMID
- 22585946
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99679193402621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Peripheral Vascular Disease
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Source: InCites