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Long Chain Omega-3 Polyunsaturated Fatty Acids Improve Vascular Stiffness in Abdominal Aortic Aneurysm - A Randomized Controlled Trial369.00 kB
Published VersionCC BY V4.0, Open Access
Journal article
Long Chain Omega-3 Polyunsaturated Fatty Acids Improve Vascular Stiffness in Abdominal Aortic Aneurysm: A Randomized Controlled Trial
Nutrients, Vol.13(1), pp.1-9
2021
Abstract
Abdominal aortic aneurysm (AAA) is a vascular disease involving permanent focal dila-tion of the abdominal aorta (≥30 mm) that can lead to catastrophic rupture. Destructive remodeling of aortic connective tissue in AAA contributes to wall stiffening, a mechanical parameter of the arterial system linked to a heightened risk of cardiovascular morbidity and mortality. Since aortic stiffening is associated with AAA progression, treatment options that target vascular inflammation would appear prudent. Given this, and growing evidence indicating robust anti-inflammatory and vasoprotective properties for long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs), this study evaluated the impact of these nutrients (1.8 g/day for 12 weeks) on indices of vascular stiffness in patients with AAA. At baseline, pulse wave velocity (PWV) and augmentation index normalized to a heart rate of 75 bpm (AIx75) were significantly higher in patients with AAA compared to control participants (PWV: 14.2 ± 0.4 m.s −1 vs. 12.6 ± 0.4 m.s −1 , p = 0.014; AIx75: 26.4 ± 1.7% vs. 17.3 ± 2.7%, p = 0.005). Twelve-week LC n-3 PUFA supplementation significantly decreased PWV (baseline: 14.2 ± 0.6 m.s −1 , week 12: 12.8 ± 0.7 m.s −1 , p = 0.014) and heart rate (baseline: 63 ± 3 bpm, week 12: 58 ± 3 bpm, p = 0.009) in patients with AAA. No change was observed for patients receiving placebo capsules. While this raises the possibility that LC n-3 PUFAs provide improvements in aortic stiffness in patients with AAA, the clinical implications remain to be fully elucidated.
Details
- Title
- Long Chain Omega-3 Polyunsaturated Fatty Acids Improve Vascular Stiffness in Abdominal Aortic Aneurysm: A Randomized Controlled Trial
- Authors
- Lara Meital (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyKarl Schulze (Author) - Sunshine VascularRebecca Magee (Author) - Sunshine Coast University Hospital (Australia)Jill O'Donnell (Author) - Sunshine Coast University Hospital (Australia)Pankaj Jha (Author) - Sunshine Coast University Hospital (Australia)Chaim Y Meital (Author) - Moffat Beach Family Medical PracticeRebecca Donkin (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyTom G Bailey (Author) - The University of QueenslandChristopher Askew (Author) - University of the Sunshine Coast, Queensland, School of Health and Sport Sciences - LegacyFraser Russell (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
- Publication details
- Nutrients, Vol.13(1), pp.1-9
- Publisher
- MDPI AG
- Date published
- 2021
- DOI
- 10.3390/nu13010138
- ISSN
- 2072-6643
- Copyright note
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
- Organisation Unit
- School of Health - Biomedicine; UniSC Clinical Trials Centre; University of the Sunshine Coast, Queensland; Cancer Research Cluster; School of Health - Sports & Exercise Science; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99498008702621
- Output Type
- Journal article
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