Local Short-Chain Fatty Acids Supplementation without Beneficial Effect on Inflammation in Excluded Rectum

J Schauber; T Bark; E Jaramillo; Mohammad Katouli; B Sandstedt; T Svenberg

doi:10.1080/003655200750024371

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Local Short-Chain Fatty Acids Supplementation without Beneficial Effect on Inflammation in Excluded Rectum

Journal article

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Local Short-Chain Fatty Acids Supplementation without Beneficial Effect on Inflammation in Excluded Rectum

J Schauber, T Bark, E Jaramillo, Mohammad Katouli, B Sandstedt and T Svenberg

Scandinavian Journal of Gastroenterology, Vol.35(2), pp.184-189

2000

DOI: https://doi.org/10.1080/003655200750024371

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Abstract

Clinical Sciences

colon flora

diversion colitis

intestinal inflammation

short-chain fatty acids

Background: Rectal instillation of short-chain fatty acids (SCFA), important nutrients for the colorectal mucosa, has been suggested to be of therapeutic value in distal intestinal inflammation. Methods: In this study nine patients with Hartmann-closed rectum after colectomy for acute colitis were investigated. In a double-blind crossover trial an enema containing SCFA or a placebo solution was administered twice daily for 3 weeks. Before entry into the protocol, after each treatment period, and 6 weeks after the study period the patients' symptoms were evaluated, rectal endoscopy was performed, histologic samples were scored, and microbiologic analyses were carried out. Results: No significant differences in symptoms, in mucosal inflammation, in histologic scoring, or in microbiologic studies were found between SCFA and placebo periods. Unexpectedly, all but one patient entirely lacked coliform bacteria in the rectum. Conclusions: In this study SCFA enemas had no beneficial effect on inflammation in excluded rectum in patients earlier submitted to colectomy for colitis. However, a different rectal flora was detected in these patients.

Details

Title: Local Short-Chain Fatty Acids Supplementation without Beneficial Effect on Inflammation in Excluded Rectum
Authors: J Schauber (Author) - Karolinska Institute, Sweden
T Bark (Author) - Karolinska Institute, Sweden
E Jaramillo (Author) - Karolinska Institute, Sweden
Mohammad Katouli (Author) - Karolinska Institute, Sweden
B Sandstedt (Author) - Karolinska Institute, Sweden
T Svenberg (Author) - Karolinska Institute, Sweden
Publication details: Scandinavian Journal of Gastroenterology, Vol.35(2), pp.184-189
Publisher: Informa Healthcare
Date published: 2000
DOI: 10.1080/003655200750024371
ISSN: 0036-5521
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450153902621
Output Type: Journal article

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