Journal article
Liver fibrosis alters the molecular structures of hepatic glycogen
Carbohydrate Polymers, Vol.278, pp.1-8
2022
PMID: 34973794
Abstract
Liver fibrosis (LF) leads to liver failure and short survival. Liver glycogen is a hyperbranched glucose polymer, comprising individual β particles, which can bind together to form aggregated α particles. Glycogen functionality depends on its molecular structure. This study compared the molecular structure of liver glycogen from both LF and healthy rats, and explored underlying mechanisms for observed differences. Glycogen from both groups contained α and β particles; the LF group contained a higher proportion of β particles, with the glycogen containing fewer long chains than seen in the control group. Both glycogen branching enzyme and glycogen phosphorylase showed a significant decrease of activity in the LF group. Transcriptomics and proteomics revealed a functional deficiency of mitochondria in the LF group, which may lead to changes in glycogen structure. These results provide for the first time an understanding of how liver fibrosis affects liver glycogen metabolism and glycogen structure.
Details
- Title
- Liver fibrosis alters the molecular structures of hepatic glycogen
- Authors
- Yujun Wan - University of QueenslandZhenxia Hu - Wuhan UniversityQinghua Liu - Xuzhou Medical CollegeLiang Wang - Xuzhou Medical CollegeMitchell A Sullivan (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - BiomedicineRobert G. Gilbert (Corresponding Author) - University of Queensland
- Publication details
- Carbohydrate Polymers, Vol.278, pp.1-8
- Publisher
- Elsevier Ltd
- Date published
- 2022
- DOI
- 10.1016/j.carbpol.2021.118991
- ISSN
- 1879-1344
- PMID
- 34973794
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035093802621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Chemistry, Applied
- Chemistry, Organic
- Polymer Science
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Source: InCites