Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Trong D Tran; Steven M Ogbourne; Peter Brooks; Norberto Sánchez-Cruz; José L Medina-Franco; Ronald J Quinn

doi:10.3390/ijms21144988

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Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Journal article

Open access

Peer reviewed

Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components

Trong D Tran, Steven M Ogbourne, Peter Brooks, Norberto Sánchez-Cruz, José L Medina-Franco and Ronald J Quinn

International Journal of Molecular Sciences, Vol.21(14), pp.1-35

2020

DOI: https://doi.org/10.3390/ijms21144988

PMCID: PMC7404124

PMID: 32679731

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Abstract

honey bee propolis

stingless bee propolis

natural products

phenolics

terpenoids

chemoinformatics

chemical space

chemical diversity

Propolis is a natural resinous material produced by bees and has been used in folk medicines since ancient times. Due to it possessing a broad spectrum of biological activities, it has gained significant scientific and commercial interest over the last two decades. As a result of searching 122 publications reported up to the end of 2019, we assembled a unique compound database consisting of 578 components isolated from both honey bee propolis and stingless bee propolis, and analyzed the chemical space and chemical diversity of these compounds. The results demonstrated that both honey bee propolis and stingless bee propolis are valuable sources for pharmaceutical and nutraceutical development.

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Title: Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components
Authors: Trong D Tran (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - Legacy
Steven M Ogbourne (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - Legacy
Peter Brooks (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - Legacy
Norberto Sánchez-Cruz (Author) - Universidad Nacional Autónoma de México
José L Medina-Franco (Author) - Universidad Nacional Autónoma de México
Ronald J Quinn (Author) - Griffith University
Publication details: International Journal of Molecular Sciences, Vol.21(14), pp.1-35
Publisher: MDPI AG
Date published: 2020
DOI: 10.3390/ijms21144988
PMID: 32679731; PMC7404124
Copyright note: Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99465007302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary

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