Leptospirosis and Goodpasture's syndrome: testing the aetiological hypothesis

Scott B Craig; Glenn C Graham; M A Burns; M F Dohnt; R J Wilson; Lee D Smythe; C C Jansen; David B McKay

doi:10.1179/000349809X12459740922336

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Leptospirosis and Goodpasture's syndrome: testing the aetiological hypothesis

Journal article

Peer reviewed

Leptospirosis and Goodpasture's syndrome: testing the aetiological hypothesis

Scott B Craig, Glenn C Graham, M A Burns, M F Dohnt, R J Wilson, Lee D Smythe, C C Jansen and David B McKay

Annals of Tropical Medicine and Parasitology, Vol.103(7), pp.647-651

2009

DOI: https://doi.org/10.1179/000349809X12459740922336

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Abstract

Goodpasture's syndrome

leptospirosis

pulmonary-renal syndrome

auto-immune diseases

Leptospiral pathogens have a world-wide distribution and cause a spectrum of disease ranging from a mild, influenza-like illness to Weil's disease, which manifests itself in multi-organ failure. Recently, Leptospira-reactive sera from 40 leptospirosis patients were investigated in an ELISA designed to detect antibodies to the human glomerular basement membrane (GBM). The aim was to determine if host-derived leptospiral immunoglobulins cross-react with proteins in the human GBM, so facilitating the development of Goodpasture's syndrome. As all 40 sera were found negative in the anti-GBM ELISA, the hypothesis that, during the immune phase of leptospirosis, patients are at risk of developing Goodpasture's syndrome was not supported. Further work is required to determine if leptospirosis is a risk factor in the development of any other pulmonary-renal syndromes that are associated with auto-immune diseases, such as Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, Behçet's disease, IgA nephropathy and systemic lupus erythematosus.

Details

Title: Leptospirosis and Goodpasture's syndrome: testing the aetiological hypothesis
Authors: Scott B Craig (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
Glenn C Graham (Author) - Queensland Health Forensic and Scientific Service
M A Burns (Author) - Queensland Health Forensic and Scientific Service
M F Dohnt (Author) - Queensland Health Forensic and Scientific Service
R J Wilson (Author) - Royal Brisbane and Women's Hospital
Lee D Smythe (Author) - Queensland Health Forensic and Scientific Service
C C Jansen (Author) - Queensland Health Forensic and Scientific Service
David B McKay (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
Publication details: Annals of Tropical Medicine and Parasitology, Vol.103(7), pp.647-651
Publisher: Maney Publishing
DOI: 10.1179/000349809X12459740922336
ISSN: 0003-4983
Organisation Unit: University of the Sunshine Coast, Queensland; School of Science and Engineering - Legacy; School of Science, Technology and Engineering
Language: English
Record Identifier: 99449863302621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Parasitology; Public, Environmental & Occupational Health; Tropical Medicine

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