Journal article
Latitude variation in pancreatic cancer mortality in Australia
Pancreas, Vol.38(4), pp.387-390
2009
Abstract
OBJECTIVES: Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of Australia and investigating if there is a role of vitamin D-effective ultraviolet radiation (DUVR), which is related to latitude. METHODS: Mortality data from 1968 to 2005 were sourced from the Australian General Record of Incidence and Mortality books. Negative binomial models were fitted to calculate the association between state and PaCa mortality. Clear sky monthly DUVR in each capital city was also modeled. RESULTS: Mortality from PaCa was 10% higher in southern states than in Queensland, with those in Victoria recording the highest mortality risk (relative risk, 1.13; 95% confidence interval, 1.09-1.17). We found a highly significant association between DUVR and PaCa mortality, with an estimated 1.5% decrease in the risk per 10-kJ/m increase in yearly DUVR. CONCLUSIONS: These data show an association between latitude, DUVR, and PaCa mortality. Although this study cannot be used to infer causality, it supports the need for further investigations of a possible role of vitamin D in PaCa etiology. © 2009 Lippincott Williams & Wilkins, Inc.
Details
- Title
- Latitude variation in pancreatic cancer mortality in Australia
- Authors
- R E Neale (Author) - Queensland Institute of Medical ResearchD R Youlden (Author) - Cancer Council QueenslandL Krnjacki (Author) - Cancer Council QueenslandMichael G Kimlin (Author) - Queensland University of TechnologyJ C Van Der Pols (Author) - Queensland Institute of Medical Research
- Publication details
- Pancreas, Vol.38(4), pp.387-390
- Publisher
- Lippincott Williams & Wilkins
- Date published
- 2009
- DOI
- 10.1097/MPA.0b013e31819975f4
- ISSN
- 0885-3177
- Organisation Unit
- University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
- Language
- English
- Record Identifier
- 99449295502621
- Output Type
- Journal article
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- Domestic collaboration
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- Gastroenterology & Hepatology
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Source: InCites