Lateral shearing interferometry, dynamic wavefront sensing, and high-speed videokeratoscopy for noninvasive assessment of tear film surface characteristics: a comparative study

Dorota H. Szczesna; David Alonso-Caneiro; D. Robert Iskander; Scott A. Read; Michael J. Collins

doi:10.1117/1.3431103

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Lateral shearing interferometry, dynamic wavefront sensing, and high-speed videokeratoscopy for noninvasive assessment of tear film surface characteristics: a comparative study

Journal article

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Lateral shearing interferometry, dynamic wavefront sensing, and high-speed videokeratoscopy for noninvasive assessment of tear film surface characteristics: a comparative study

Dorota H. Szczesna, David Alonso-Caneiro, D. Robert Iskander, Scott A. Read and Michael J. Collins

Journal of Biomedical Optics, Vol.15(3), pp.1-9

2010

DOI: https://doi.org/10.1117/1.3431103

PMID: 20615034

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Abstract

tear film kinetics

videokeratoscopy

wavefront sensing

interferometry

There are several noninvasive techniques for assessing the kinetics of tear film, but no comparative studies have been conducted to evaluate their efficacies. Our aim is to test and compare techniques based on high-speed videokeratoscopy (HSV), dynamic wavefront sensing (DWS), and lateral shearing interferometry (LSI). Algorithms are developed to estimate the tear film build-up time T(BLD), and the average tear film surface quality in the stable phase of the interblink interval TFSQ(Av). Moderate but significant correlations are found between T(BLD) measured with LSI and DWS based on vertical coma (Pearson's r(2) = 0.34, p<0.01) and higher order rms (r(2) = 0.31, p<0.01), as well as between TFSQ(Av) measured with LSI and HSV (r(2) = 0.35, p<0.01), and between LSI and DWS based on the rms fit error (r(2) = 0.40, p<0.01). No significant correlation is found between HSV and DWS. All three techniques estimate tear film build-up time to be below 2.5 sec, and they achieve a remarkably close median value of 0.7 sec. HSV appears to be the most precise method for measuring tear film surface quality. LSI appears to be the most sensitive method for analyzing tear film build-up.

Details

Title: Lateral shearing interferometry, dynamic wavefront sensing, and high-speed videokeratoscopy for noninvasive assessment of tear film surface characteristics: a comparative study
Authors: Dorota H. Szczesna (Corresponding Author) - Wrocław University of Science and Technology
David Alonso-Caneiro (Author) - Queensland University of Technology
D. Robert Iskander (Author) - Queensland University of Technology
Scott A. Read (Author) - Queensland University of Technology
Michael J. Collins (Author) - Queensland University of Technology
Publication details: Journal of Biomedical Optics, Vol.15(3), pp.1-9
Publisher: S P I E - International Society for Optical Engineering
Date published: 2010
DOI: 10.1117/1.3431103
ISSN: 1560-2281
PMID: 20615034
Grant note: ERF08_PDR_884 / Endeavour Research Fellowship
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99973598602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging

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