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Late components of the event-related potentials and their topography in Parkinson's disease
Journal article   Peer reviewed

Late components of the event-related potentials and their topography in Parkinson's disease

Jim Lagopoulos, P Clouston, H Barhamali, E Gordon, W M Li, J Lesley and J G L Morris
Movement Disorders, Vol.13(2), pp.262-267
1998
url
https://doi.org/10.1002/mds.870130211View
Published Version

Abstract

reaction tim event-related potentia topography
Late components of the event-related potential (ERP; N100, P200, N200, and P300) were elicited using an auditory oddball paradigm (with a button-press response to target stimuli) in 15 Parkinson's disease (PD) patients and 50 normal control subjects. Compared with control subjects, PD subjects showed a significant decrease in N200 amplitude. Between-group topographical differences in N200 amplitude were evident at central (C3, Cz, C4) and temporal (T5, T3, T4, T6) regions. The results may reflect a deficit in response selection in PD possibly resulting from a dysfunction associated with the abnormalities in the central and temporal regions found to have a decreased N200 amplitude compared with normal control subjects in this study.

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Clinical Neurology

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