Large-Pore Periodic Mesoporous Organosilicas as Advanced Bactericide Platforms

Albane Birault; Emilie Molina; Guillaume Toquer; Patrick Lacroix-Desmazes; Nathalie Marcote; Carole Carcel; Mohammad Katouli; John R Bartlett; Corine Gerardin; Michel Wong Chi Man

doi:10.1021/acsabm.8b00474

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Large-Pore Periodic Mesoporous Organosilicas as Advanced Bactericide Platforms

Journal article

Peer reviewed

Large-Pore Periodic Mesoporous Organosilicas as Advanced Bactericide Platforms

Albane Birault, Emilie Molina, Guillaume Toquer, Patrick Lacroix-Desmazes, Nathalie Marcote, Carole Carcel, Mohammad Katouli, John R Bartlett, Corine Gerardin and Michel Wong Chi Man

ACS Applied Bio Materials, Vol.1(6), pp.1787-1792

2018

DOI: https://doi.org/10.1021/acsabm.8b00474

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Abstract

antibiotic delivery systems

crystal-like mesostructure

hybrid materials

periodic mesoporous organosilicas

polyion complex micelles

sol-gel process

Despite the versatility of periodic mesoporous organosilicas (PMOs), the bactericide capacity of these hybrid platforms has seldom been explored. Herein, we describe the synthesis of large-pore phenylene-bridged PMOs, mesostructured by polyion complex (PIC) micelles (PICPMOs) incorporating an antibiotic, neomycin B. A key feature of this approach is that the bioactive molecules are directly encapsulated within the PICPMOs during their formation. The engineered PICPMOs exhibit a well-ordered hexagonal mesophase with a molecular-scale crystallinity and large mesopores (8 nm), which facilitates pH-triggered delivery of the drug. The results obtained with a pathogenic Escherichia coli strain clearly demonstrate the potential of such PICPMOs for antibacterial applications.

Details

Title: Large-Pore Periodic Mesoporous Organosilicas as Advanced Bactericide Platforms
Authors: Albane Birault (Author) - Univ Montpellier, France
Emilie Molina (Author) - Univ Montpellier, France
Guillaume Toquer (Author) - Univ Montpellier, France
Patrick Lacroix-Desmazes (Author) - Univ Montpellier, France
Nathalie Marcote (Author) - Univ Montpellier, France
Carole Carcel (Author) - Univ Montpellier, France
Mohammad Katouli (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
John R Bartlett (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Corine Gerardin (Author) - Univ Montpellier, France
Michel Wong Chi Man (Author) - Univ Montpellier, France
Publication details: ACS Applied Bio Materials, Vol.1(6), pp.1787-1792
Publisher: American Chemical Society
Date published: 2018
DOI: 10.1021/acsabm.8b00474
ISSN: 2576-6422
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451126102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Materials Science, Biomaterials; Nanoscience & Nanotechnology