Lack of cognitive impairment in long-term survivors of colorectal cancer

Janette L Vardy; Gregory R Pond; Lucette A Cysique; Thomas M Gates; Jim Lagopoulos; Corrinne Renton; Louise M Waite; Ian F Tannock; Haryana M Dhillon

doi:10.1007/s00520-022-07008-3

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Lack of cognitive impairment in long-term survivors of colorectal cancer

Journal article

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Peer reviewed

Lack of cognitive impairment in long-term survivors of colorectal cancer

Janette L Vardy, Gregory R Pond, Lucette A Cysique, Thomas M Gates, Jim Lagopoulos, Corrinne Renton, Louise M Waite, Ian F Tannock and Haryana M Dhillon

Supportive Care in Cancer, Vol.30(7), pp.6123-6133

2022

DOI: https://doi.org/10.1007/s00520-022-07008-3

PMID: 35420329

Appears in Thompson Institute Research Collection

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Abstract

cognitive function

survivorship

colorectal cancer

Other Collaborations

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

Background: Our longitudinal study reported cognitive impairment in 43% of people following diagnosis of localised colorectal cancer (CRC) versus 15% in healthy controls (p < 0.001) and 50% versus 13% 1–2 years later (p < 0.001). Here we evaluate cognitive function and neuroimaging in a subgroup at long-term follow-up. Patients and methods: Cancer-free Australian participants in the study, and controls, completed cognitive and functional assessments. Neuroimaging was optional. Blood tests included inflammatory markers, clotting factors, sex hormones and apolipoprotein E genotype. The primary endpoint was demographically and practice effect-corrected cognitive scores comparing CRC survivors with controls over time examined using a linear mixed model, adjusted for baseline performance. Secondary endpoints included cognitive impairment rate using the Global Deficit Score [GDS > 0.5], Functional Deficit Score, blood results and neuroimaging. Results: The study included 25 CRC survivors (60% men, median age 72) at mean 9 years after baseline (9 received adjuvant chemotherapy) and 25 controls (44% men, median age 68) at mean 6 years after baseline. There were no significant differences in cognitive scores or proportion with cognitive impairment (16 vs. 8%) between survivors and controls and no evidence of accelerated ageing in CRC survivors. Baseline cognitive performance predicted for subsequent cognitive function. There were no differences in functional tests or blood tests between groups. In 18 participants undergoing neuroimaging, 10 CRC survivors had higher myoinositol levels than 8 controls, and lower volume in the right amygdala and caudate and left hippocampal regions. Conclusions: There was no difference in cognitive capacity and function between CRC survivors and controls 6–12 years after diagnosis. Differences in neuroimaging require confirmation in a larger sample.

Details

Title: Lack of cognitive impairment in long-term survivors of colorectal cancer
Authors: Janette L Vardy (Corresponding Author) - The University of Sydney
Gregory R Pond (Author) - McMaster University
Lucette A Cysique (Author) - UNSW Australia
Thomas M Gates (Author) - UNSW Australia
Jim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Corrinne Renton (Author) - The University of Sydney
Louise M Waite (Author) - Concord Repatriation General Hospital
Ian F Tannock (Author) - Princess Margaret Cancer Centre
Haryana M Dhillon (Author) - The University of Sydney
Publication details: Supportive Care in Cancer, Vol.30(7), pp.6123-6133
Publisher: Springer
Date published: 2022
DOI: 10.1007/s00520-022-07008-3
ISSN: 1433-7339; 0941-4355
PMID: 35420329
Copyright note: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Grant note: APP1176221 / National Health & Medical Research Council Australia
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99629435702621
Output Type: Journal article

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Web Of Science research areas: Health Care Sciences & Services; Oncology; Rehabilitation

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