Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways

Nina M Pollak; Matthew Hoffman; Ira J Goldberg; Konstantinos Drosatos

doi:10.1016/j.jacbts.2017.09.001

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Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways

Journal article

Open access

Peer reviewed

Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways

Nina M Pollak, Matthew Hoffman, Ira J Goldberg and Konstantinos Drosatos

JACC: Basic to Translational Science, Vol.3(1), pp.132-156

2018

DOI: https://doi.org/10.1016/j.jacbts.2017.09.001

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Abstract

Clinical Sciences

diabetes

heart failure

metabolism

obesity

Krüppel-like factors

Krüppel-like factors (KLFs) are deoxyribonucleic acid-binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ, or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. This review article summarizes the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease.

Details

Title: Krüppel-Like Factors: Crippling and Uncrippling Metabolic Pathways
Authors: Nina M Pollak (Author) - University of Queensland
Matthew Hoffman (Author) - Temple University, United States
Ira J Goldberg (Author) - New York School of Medicine, United States
Konstantinos Drosatos (Author) - Temple University, United States
Publication details: JACC: Basic to Translational Science, Vol.3(1), pp.132-156
Publisher: Elsevier Inc.
Date published: 2018
DOI: 10.1016/j.jacbts.2017.09.001
ISSN: 2452-302X
Copyright note: Copyright © 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451151902621
Output Type: Journal article

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112 Times Cited - Web of Science

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Cardiac & Cardiovascular Systems

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Source: InCites