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Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma938.71 kB
Published VersionCC BY V4.0, Open Access
Journal article
Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma
Virology Journal, Vol.17, pp.1-4
2020
Abstract
Koala retrovirus (KoRV) is believed to be in an active state of endogenization into the koala genome. KoRV is present as both an endogenous and exogenous infection in all koalas in northern Australia. KoRV has been linked to koala pathologies including neoplasia and increased susceptibility to Chlamydia. A KoRV vaccine recently trialled in 10 northern koalas improved antibody response and reduced viral load. This communication reports the expression of key immune genes underlining the innate and adaptive immune response to vaccination in these northern koalas. The results showed that prior to vaccination, IL-8 was expressed at the highest levels, with at least 200-fold greater expression compared to other cytokines, while CD8 mRNA expression was significantly higher than CD4 mRNA expression level. Interferon-γ was up-regulated at both 4- and 8-weeks post-vaccination while IL-8 was down-regulated at 8-weeks post-vaccination.
Details
- Title
- Koalas vaccinated against Koala retrovirus respond by producing increased levels of interferon-gamma
- Authors
- Olusola Olagoke (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyBonnie Quigley (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - LegacyPeter Timms (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
- Publication details
- Virology Journal, Vol.17, pp.1-4
- Publisher
- BioMed Central Ltd.
- Date published
- 2020
- DOI
- 10.1186/s12985-020-01442-7
- ISSN
- 1743-422X
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Organisation Unit
- School of Health and Sport Sciences - Legacy; Thompson Institute; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99487108902621
- Output Type
- Journal article
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