Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala populations than koala retrovirus subtypes

Amy Robbins; Jonathan Hanger; Martina Jelocnik; Bonnie L Quigley; Peter Timms

doi:10.1038/s41598-020-72050-2

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Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala populations than koala retrovirus subtypes

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Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala populations than koala retrovirus subtypes

Amy Robbins, Jonathan Hanger, Martina Jelocnik, Bonnie L Quigley and Peter Timms

Scientific Reports, Vol.10(1), pp.1-13

2020

DOI: https://doi.org/10.1038/s41598-020-72050-2

PMCID: PMC7490398

PMID: 32929174

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Abstract

Bacterial infection

Conservation biology

Chlamydial disease control is increasingly utilised as a management tool to stabilise declining koala populations, and yet we have a limited understanding of the factors that contribute to disease progression. To examine the impact of host and pathogen genetics, we selected two geographically separated south east Queensland koala populations, differentially affected by chlamydial disease, and analysed koala major histocompatibility complex (MHC) genes, circulating strains of Chlamydia pecorum and koala retrovirus (KoRV) subtypes in longitudinally sampled, well-defined clinical groups. We found that koala immunogenetics and chlamydial genotypes differed between the populations. Disease progression was associated with specific MHC alleles, and we identified two putative susceptibility (DCb 03, DBb 04) and protective (DAb 10, UC 01:01) variants. Chlamydial genotypes belonging to both Multi-Locus Sequence Typing sequence type (ST) 69 and ompA genotype F were associated with disease progression, whereas ST 281 was associated with the absence of disease. We also detected different ompA genotypes, but not different STs, when long-term infections were monitored over time. By comparison, KoRV profiles were not significantly associated with disease progression. These findings suggest that chlamydial genotypes vary in pathogenicity and that koala immunogenetics and chlamydial strains are more directly involved in disease progression than KoRV subtypes.

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Title: Koala immunogenetics and chlamydial strain type are more directly involved in chlamydial disease progression in koalas from two south east Queensland koala populations than koala retrovirus subtypes
Authors: Amy Robbins (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - Legacy
Jonathan Hanger (Author) - Endeavour Veterinary Ecology Pty Ltd
Martina Jelocnik (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Bonnie L Quigley (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Peter Timms (Corresponding Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Publication details: Scientific Reports, Vol.10(1), pp.1-13
Publisher: Nature Publishing Group
Date published: 2020
DOI: 10.1038/s41598-020-72050-2
PMID: 32929174; PMC7490398
Copyright note: Copyright © The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creat iveco mmons .org/licen ses/by/4.0/.
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99480007502621
Output Type: Journal article

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