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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure
iScience, Vol.24(11), pp.2-24
2021
PMID: 34820603
Abstract
The kidneys balance many byproducts of the metabolism of dietary components. Previous studies examining dietary effects on kidney health are generally of short duration and manipulate a single macronutrient. Here, kidney function and structure were examined in C57BL/6J mice randomized to consume one of a spectrum of macronutrient combinations (protein 15%-60%], carbohydrate 120%-75%), and fat 120%-75%]) from weaning to late-middle age (15 months). Individual and interactive impacts of macronutrients on kidney health were modeled. Dietary protein had the greatest influence on kidney function, where chronic low protein intake decreased glomerular filtration rates and kidney mass, whereas it increased kidney immune infiltration and structural injury. Kidney outcomes did not align with cardiometabolic risk factors including glucose intolerance, overweigF"obesity, dye: ' "a, and hypertension in mice with chronic low protein consumption. This study highlights that protein intake over a lifespan is an important determinant of kidney function independent of cardiometabolic changes.
Details
- Title
- Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure
- Authors
- Amelia K Fotheringham - The University of QueenslandSamantha M Solon-Biet - The University of SydneyHelle Bielefeldt-Ohmann - The University of QueenslandDomenica A McCarthy - Translational Research InstituteAisling C. McMahon - Anzac Research InstituteKari RuohonenIsaac Li - The University of QueenslandMitchell A Sullivan - The University of QueenslandRani Whiddett - Mater ResearchDanielle Borg - The University of QueenslandVictoria C Cogger - Anzac Research InstituteWilliam O. Ballard - UNSW SydneyNigel Turner - UNSW SydneyRichard G. Melvin - University of Minnesota, DuluthDavid Raubenheimer - The University of SydneyDavid G Le Couteur - Anzac Research InstituteStephen J Simpson - The University of SydneyJosephine M Forbes (Corresponding Author) - The University of Queensland
- Publication details
- iScience, Vol.24(11), pp.2-24
- Publisher
- Cell Press
- Date published
- 2021
- DOI
- 10.1016/j.isci.2021.103308
- ISSN
- 2589-0042
- PMID
- 34820603
- Copyright note
- (c) 2021 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- Data Availability
- The datasets supporting the current study have not been deposited in a public repository but are available from the corresponding author on request. This study did not generate any code.
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035094202621
- Output Type
- Journal article
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- Web Of Science research areas
- Urology & Nephrology
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