KPNA3 Variation Is Associated with Schizophrenia, Major Depression, Opiate Dependence and Alcohol Dependence

Charles P Morris; Bernhard T Baune; Katharina Domschke; Volker Arolt; Christopher D Swagell; Ian P Hughes; Bruce R Lawford; Ross Young; Joanne Voisey

doi:10.3233/DMA-2012-0921

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KPNA3 Variation Is Associated with Schizophrenia, Major Depression, Opiate Dependence and Alcohol Dependence

Journal article

Open access

Peer reviewed

KPNA3 Variation Is Associated with Schizophrenia, Major Depression, Opiate Dependence and Alcohol Dependence

Charles P Morris, Bernhard T Baune, Katharina Domschke, Volker Arolt, Christopher D Swagell, Ian P Hughes, Bruce R Lawford, Ross Young and Joanne Voisey

Disease Markers, Vol.33(4), pp.163-170

2012

DOI: https://doi.org/10.3233/DMA-2012-0921

PMCID: PMC3810702

PMID: 22960338

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Abstract

KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level. Major depression was also associated with rs2273816 but only at the allele level. Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders.

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Title: KPNA3 Variation Is Associated with Schizophrenia, Major Depression, Opiate Dependence and Alcohol Dependence
Authors: Charles P Morris (Author) - Queensland University of Technology
Bernhard T Baune (Author) - The University of Adelaide
Katharina Domschke (Author) - University of Muenster
Volker Arolt (Author) - University of Muenster
Christopher D Swagell (Author) - Queensland University of Technology
Ian P Hughes (Author) - Queensland University of Technology
Bruce R Lawford (Author) - 61USC_INST___RBH
Ross Young (Author) - Queensland University of Technology
Joanne Voisey (Author) - Queensland University of Technology
Publication details: Disease Markers, Vol.33(4), pp.163-170
Publisher: Hindawi Limited
Date published: 2012
DOI: 10.3233/DMA-2012-0921
ISSN: 1875-8630; 0278-0240
PMID: 22960338; PMC3810702
Copyright note: Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisation Unit: University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
Language: English
Record Identifier: 99551706302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental; Pathology

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