KIBRA gene polymorphism has no association with verbal or visual episodic memory performance

Katherine H Franks; Mathew J Summers; James C Vickers

doi:10.3389/fnagi.2014.00270

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KIBRA gene polymorphism has no association with verbal or visual episodic memory performance

Journal article

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KIBRA gene polymorphism has no association with verbal or visual episodic memory performance

Katherine H Franks, Mathew J Summers and James C Vickers

Frontiers in Aging Neuroscience, Vol.6, 270

2014

DOI: https://doi.org/10.3389/fnagi.2014.00270

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Abstract

Neurosciences

KIBRA

WWC1

episodic memory

aging

single-nucleotide polymorphism

Inter-individual variability in memory performance has been suggested to result, in part, from genetic differences in the coding of proteins involved in long-term potentiation (LTP). The present study examined the effect of a single-nucleotide polymorphism (SNP) in the KIBRA gene (rs17070145) on episodic memory performance, using multiple measures of verbal and visual episodic memory. A total of 256 female and 130 male healthy, older adults (mean age = 60.86 years) were recruited from the Tasmanian Healthy Brain Project (THBP), undergoing both neuropsychological and genetic testing. The current study showed no significant effect of the KIBRA polymorphism on performance on the Rey Auditory Verbal Learning Task, Logical Memory test, Paired Associates Learning test or Rey Complex Figure Task. The results suggest there is little to no functional significance of KIBRA genotype on episodic memory performance, regardless of modality.

Details

Title: KIBRA gene polymorphism has no association with verbal or visual episodic memory performance
Authors: Katherine H Franks (Author) - University of Tasmania
Mathew J Summers (Author) - University of Tasmania
James C Vickers (Author) - University of Tasmania
Publication details: Frontiers in Aging Neuroscience, Vol.6, 270; 6
Publisher: Frontiers Research Foundation
Date published: 2014
DOI: 10.3389/fnagi.2014.00270
ISSN: 1663-4365
Copyright note: Copyright © 2014 Franks, Summers and Vickers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Organisation Unit: School of Health; School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Psychology; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99448752202621
Output Type: Journal article

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