Isolation of Tetracycline-Resistant Chlamydia suis from a Pig Herd Affected by Reproductive Disorders and Conjunctivitis

Christine Unterweger; Lukas Schwarz; Martina Jelocnik; Nicole Borel; Rene Brunthaler; Aleksandra Inic-Kanada; Hanna Marti

doi:10.3390/antibiotics9040187

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Isolation of Tetracycline-Resistant Chlamydia suis from a Pig Herd Affected by Reproductive Disorders and Conjunctivitis

Journal article

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Peer reviewed

Isolation of Tetracycline-Resistant Chlamydia suis from a Pig Herd Affected by Reproductive Disorders and Conjunctivitis

Christine Unterweger, Lukas Schwarz, Martina Jelocnik, Nicole Borel, Rene Brunthaler, Aleksandra Inic-Kanada and Hanna Marti

Antibiotics, Vol.9(4), 187

2020

DOI: https://doi.org/10.3390/antibiotics9040187

Appears in UniSC Diversity and Inclusion Research Collection

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Abstract

chlamydia suis

fertility problems

conjunctivitis

minimal inhibition concentration

multilocus sequence typing

recovery testing

tetracycline resistance

UniSC Diversity Area - Disability and Inclusion

Due to various challenges in diagnosing chlamydiosis in pigs, antibiotic treatment is usually performed before any molecular or antibiotic susceptibility testing. This could increase the occurrence of tetracycline-resistant Chlamydia (C.) suis isolates in the affected pig population and potentiate the reoccurrence of clinical signs. Here, we present a case of an Austrian pig farm, where tetracycline resistant and sensitive C. suis isolates were isolated from four finishers with conjunctivitis. On herd-level, 10% of the finishers suffered from severe conjunctivitis and sows showed a high percentage of irregular return to estrus. Subsequent treatment of whole-herd using oxytetracycline led to a significant reduction of clinical signs. Retrospective antibiotic susceptibility testing revealed tetracycline resistance and decreased susceptibility to doxycycline in half of the ocular C. suis isolates, and all isolates were able to partially recover following a single-dose tetracycline treatment in vitro. These findings were later confirmed in vivo, when all former clinical signs recurred three months later. This case report raises awareness of tetracycline resistance in C. suis and emphasizes the importance of preventative selection of tetracycline resistant C. suis isolates.

Details

Title: Isolation of Tetracycline-Resistant Chlamydia suis from a Pig Herd Affected by Reproductive Disorders and Conjunctivitis
Authors: Christine Unterweger (Author) - University of Veterinary Medicine, Austria
Lukas Schwarz (Author) - University of Veterinary Medicine, Austria
Martina Jelocnik (Author) - University of the Sunshine Coast
Nicole Borel (Author) - Vetsuisse Faculty University Zurich, Switzerland
Rene Brunthaler (Author) - University of Veterinary Medicine, Austria
Aleksandra Inic-Kanada (Author) - Medical University of Vienna, Austria
Hanna Marti (Author) - Vetsuisse Faculty University Zurich, Switzerland
Publication details: Antibiotics, Vol.9(4), 187
Publisher: MDPI AG
Date published: 2020
DOI: 10.3390/antibiotics9040187
ISSN: 2079-6382
Copyright note: Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Organisation Unit: University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450819702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Infectious Diseases; Pharmacology & Pharmacy

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