Ionophore-based ion-selective optical nanosensors operating in exhaustive sensing mode

Xiaojiang Xie; Jingying Zhai; Gaston A Crespo; Eric Bakker

doi:10.1021/ac5019606

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Ionophore-based ion-selective optical nanosensors operating in exhaustive sensing mode

Journal article

Peer reviewed

Ionophore-based ion-selective optical nanosensors operating in exhaustive sensing mode

Xiaojiang Xie, Jingying Zhai, Gaston A Crespo and Eric Bakker

Analytical Chemistry, Vol.86(17), pp.8770-8775

2014

DOI: https://doi.org/10.1021/ac5019606

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Abstract

Analytical Chemistry

Chemical Engineering

Other Chemical Sciences

ion selective optical sensors

Ion selective optical sensors are typically interrogated under conditions where the sample concentration is not altered during measurement. We describe here an alternative exhaustive detection mode for ion selective optical sensors. This exhaustive sensor concept is demonstrated with ionophore-based nanooptodes either selective for calcium or the polycationic heparin antidote protamine. In agreement with a theoretical treatment presented here, linear calibration curves were obtained in the exhaustive detection mode instead of the sigmoidal curves for equilibrium-based sensors. The response range can be tuned by adjusting the nanosensor loading. The nanosensors showed average diameters of below 100 nm and the sensor response was found to be dramatically faster than that for film-based optodes. Due to the strong binding affinity of the exhaustive nanosensors, total calcium concentration in human blood plasma was successfully determined. Optical determination of protamine in human blood plasma using the exhaustive nanosensors was attempted, but was found to be less successful. © 2014 American Chemical Society.

Details

Title: Ionophore-based ion-selective optical nanosensors operating in exhaustive sensing mode
Authors: Xiaojiang Xie (Author) - University of Geneva, Switzerland
Jingying Zhai (Author) - University of Geneva, Switzerland
Gaston A Crespo (Author) - University of Geneva, Switzerland
Eric Bakker (Author) - University of Geneva, Switzerland
Publication details: Analytical Chemistry, Vol.86(17), pp.8770-8775
Publisher: American Chemical Society
Date published: 2014
DOI: 10.1021/ac5019606
ISSN: 0003-2700
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99448813602621
Output Type: Journal article

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