Investigation the Possibility of Using Peptides with a Helical Repeating Pattern of HydroPhobic and Hydrophilic Residues to Inhibit IL-10

Guoying Ni; Shu Chen; Yuedong Yang; Scott F Cummins; Jian Zhan; Zhixiu Li; Bin Zhu; Kate E Mounsey; Shelley F Walton; Ming Q Wei; Yuejian Wang; Yaoqi Zhou; Tianfang Wang; Xiao Song Liu

doi:10.1371/journal.pone.0153939

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Investigation the Possibility of Using Peptides with a Helical Repeating Pattern of HydroPhobic and Hydrophilic Residues to Inhibit IL-10

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Investigation the Possibility of Using Peptides with a Helical Repeating Pattern of HydroPhobic and Hydrophilic Residues to Inhibit IL-10

Guoying Ni, Shu Chen, Yuedong Yang, Scott F Cummins, Jian Zhan, Zhixiu Li, Bin Zhu, Kate E Mounsey, Shelley F Walton, Ming Q Wei, …

PLoS One, Vol.11(4), e0153939

2016

DOI: https://doi.org/10.1371/journal.pone.0153939

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Abstract

Blockade of IL-10 signalling clears chronic viral and bacterial infections. Immunization together with blockade of IL-10 signalling or relatively low level of IL-10 further enhances viral and bacterial clearance. IL-10 functions through binding to interleukin 10 receptor (IL- 10R). Here we showed that peptides P1 and P2 with the hydrophobic and hydrophilic pattern of the IL10R-binding helix in IL-10 could bind with either IL-10R1 or IL-10, and inhibit inflammatory signals with long duration and negligible cytotoxicity in vitro. Furthermore, P2 can enhance antigen specific CD8+ T cell responses in mice induced by the vaccine based on a long peptide of protein E7 in a human papillomavirus type 16

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Title: Investigation the Possibility of Using Peptides with a Helical Repeating Pattern of HydroPhobic and Hydrophilic Residues to Inhibit IL-10
Authors: Guoying Ni (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Shu Chen (Author) - Foshan First People's Hospital, China
Yuedong Yang (Author) - Griffith University
Scott F Cummins (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Jian Zhan (Author) - Griffith University
Zhixiu Li (Author) - University of Queensland
Bin Zhu (Author) - Foshan First People's Hospital, China
Kate E Mounsey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Shelley F Walton (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Ming Q Wei (Author) - Griffith University
Yuejian Wang (Author) - Foshan First People's Hospital, China
Yaoqi Zhou (Author) - Griffith University
Tianfang Wang (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: PLoS One, Vol.11(4), e0153939; 19
Publisher: Public Library of Science
Date published: 2016
DOI: 10.1371/journal.pone.0153939
ISSN: 1932-6203
Copyright note: Copyright © 2016 Ni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Organisation Unit: School of Health - Biomedicine; School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99449526702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Immunology

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