Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine

R Curtain; R A Lea; S Quinlan; C Bellis; Roger Hughes; L Tajouri; J MacMillan; L R Griffiths

doi:10.1016/j.jns.2004.08.010

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Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine

Journal article

Peer reviewed

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine

R Curtain, R A Lea, S Quinlan, C Bellis, Roger Hughes, L Tajouri, J MacMillan and L R Griffiths

Journal of the Neurological Sciences, Vol.227(1), pp.95-100

2004

DOI: https://doi.org/10.1016/j.jns.2004.08.010

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Abstract

Clinical Sciences

Neurosciences

migraine

chromosome 19

association

LDLR

polymorphism

cholesterol

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene on chromosome 19p13.2 performing an association analysis in 244 typical migraine-affected patients, 151 suffering from migraine with aura (MA), 96 with migraine without aura (MO) and 244 unaffected controls. The populations consisted of Caucasians only, and controls were age- and sex-matched. The results showed no significant difference between groups for allele frequency distributions of the (TA)n polymorphism even after separation of the migraine-affected individuals into subgroups of MA and MO affected patients. This is in contradiction to lochi et al. [Mochi M, Cevoli S, Cortelli P, Pierangeli G, Scapoli C, Soriani S, Montagna P. Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migrane without aura. J Neurol Sci 2003; 213 (1-2): 7-10.] who found a positive association of this variant with MO. Our study discusses possible differences between the two studies and extends this research by investigating circulating cholesterol levels in a migraine-affected population.

Details

Title: Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine
Authors: R Curtain (Author) - Griffith University
R A Lea (Author) - Griffith University
S Quinlan (Author) - Griffith University
C Bellis (Author) - Griffith University
Roger Hughes (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
L Tajouri (Author) - Griffith University
J MacMillan (Author) - Queensland Clinical Genetics Service
L R Griffiths (Author) - Griffith University
Publication details: Journal of the Neurological Sciences, Vol.227(1), pp.95-100
Publisher: Elsevier BV
Date published: 2004
DOI: 10.1016/j.jns.2004.08.010
ISSN: 0022-510X
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449859002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Clinical Neurology; Neurosciences

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