Journal article
Investigation of long chain omega-3 PUFAs on arterial blood pressure, vascular reactivity and survival in angiotensin II-infused Apolipoprotein E knockout mice
Clinical and Experimental Pharmacology and Physiology, Vol.43(2), pp.174-181
2016
Abstract
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease. Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) decrease inflammation and oxidative stress in an angiotensin II-infused apolipoprotein E-knockout (ApoE-/-) mouse model of AAA. We investigated the effects of LC n-3 PUFAs on blood pressure and vascular reactivity in fourteen angiotensin II-infused ApoE-/- male mice. Blood pressure was obtained using a non-invasive tail cuff method and whole blood was collected by cardiac puncture. Vascular reactivity of the thoracic aorta was assessed using wire myography and activation of endothelial nitric oxide synthase (eNOS) was determined by immunohistochemistry. A high LC n-3 PUFA diet increased the omega-3 index and reduced the n-6 to n-3 PUFA ratio. At day 10 post-infusion with angiotensin II, there was no difference in SBP or DBP in mice fed the high or low n-3 PUFA diets. The high LC n-3 PUFA diet resulted in a non-significant trend for delay in time to death from abdominal aortic rupture. Vascular reactivity and eNOS activation remained unchanged in mice fed the high compared to the low LC n-3 PUFA diet. This study argues against direct improvement in vascular reactivity in ApoE-/- mice that were supplemented with n-3 PUFA for 8 weeks prior to infusion with angiotensin II.
Details
- Title
- Investigation of long chain omega-3 PUFAs on arterial blood pressure, vascular reactivity and survival in angiotensin II-infused Apolipoprotein E knockout mice
- Authors
- Corinna S Burgin-Maunder (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringMaria Nataatmadja (Author) - University of QueenslandRebecca K Vella (Author) - Central Queensland UniversityAndrew S Fenning (Author) - Central Queensland UniversityPeter R Brooks (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringFraser D Russell (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Clinical and Experimental Pharmacology and Physiology, Vol.43(2), pp.174-181
- Publisher
- Wiley-Blackwell Publishing Asia
- Date published
- 2016
- DOI
- 10.1111/1440-1681.12520
- ISSN
- 0305-1870
- Copyright note
- Copyright © 2016 Wiley-Blackwell Publishing Asia. This is the accepted version of the following article: Bürgin-Maunder, C. S., Nataatmadja, M., Vella, R. K., Fenning, A. S., Brooks, P. R. and Russell, F. D. (2016), Investigation of long chain omega-3 PUFAs on arterial blood pressure, vascular reactivity and survival in angiotensin II-infused Apolipoprotein E-knockout mice. Clin Exp Pharmacol Physiol, 43: 174-181. doi:10.1111/1440-1681.12520, which has been published in final form at http://dx.doi.org/10.1111/1440-1681.12520
- Organisation Unit
- School of Health - Biomedicine; School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99449174702621
- Output Type
- Journal article
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