Investigating age appropriate coagulation reference intervals to support patient blood management in the elderly: A verification study

Rebecca M Donkin; Yoke Lin Fung

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Investigating age appropriate coagulation reference intervals to support patient blood management in the elderly: A verification study

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Investigating age appropriate coagulation reference intervals to support patient blood management in the elderly: A verification study

Rebecca M Donkin and Yoke Lin Fung

Annals of Clinical and Laboratory Science, Vol.50(4), pp.545-550

2020

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Abstract

Clinical Sciences

coagulation tests

reference intervals

elderly

thromboelastography

prothrombin time

activated partial thromboplastin time

Reference intervals are vital for interpreting coagulation results. Current interval ranges have no upper age limit, although there is evidence that coagulation function changes with age. This study compared coagulation results from healthy people aged >60 years against adult reference intervals for routine clotting assays and thromboelastography (TEG), to determine if reference intervals are relevant to older adults. Samples from healthy blood donors aged >60 years (n=30 male, n=30 female) were tested by TEG ® 6s, prothrombin time (PT), activated partial thromboplastin time (aPTT) and derived fibrinogen. All older donor derived fibrinogen results were within the adult reference intervals however, levels were significantly higher in females. A proportion of TEG ® 6s and aPTT results were not within the reference intervals. As populations around the world live longer, these findings question whether older adults require age specific coagulation reference intervals.

Details

Title: Investigating age appropriate coagulation reference intervals to support patient blood management in the elderly: A verification study
Authors: Rebecca M Donkin (Author) - University of the Sunshine Coast - School of Health and Sport Sciences
Yoke Lin Fung (Author) - University of the Sunshine Coast - School of Health and Sport Sciences
Publication details: Annals of Clinical and Laboratory Science, Vol.50(4), pp.545-550
Publisher: Association of Clinical Scientists
Date published: 2020
ISSN: 0097-7370
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Cancer Research Cluster; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451107602621
Output Type: Journal article

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