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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
International review of blood donation nucleic acid amplification testing
Vox Sanguinis, Vol.119(4), pp.315-325
2024
PMID: 38390819
Appears in UniSC Supported Open Access Outputs
Abstract
Background and Objectives:
Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral and parasite nucleic acids to reduce transfusion-transmitted infections. This project reviewed NAT for screening blood donations globally.
Materials and Methods:
A survey on NAT usage, developed by the International Society of Blood Transfusion Working Party on Transfusion-transmitted Infectious Diseases (ISBT WP-TTID), was distributed through ISBT WP-TTID members. Data were analysed using descriptive statistics.
Results:
Forty-three responses were received from 32 countries. Increased adoption of blood donation viral screening by NAT was observed over the past decade. NAT-positive donations were detected for all viruses tested in 2019 (proportion of donations positive by NAT were 0.0099% for human immunodeficiency virus [HIV], 0.0063% for hepatitis C virus [HCV], 0.0247% for hepatitis B virus [HBV], 0.0323% for hepatitis E virus [HEV], 0.0014% for West Nile virus [WNV] and 0.00005% for Zika virus [ZIKV]). Globally, over 3100 NAT-positive donations were identified as NAT yield or solely by NAT in 2019 and over 22,000 since the introduction of NAT, with HBV accounting for over half. NAT-positivity rate was higher in first-time donors for all viruses tested except WNV. During 2019, a small number of participants performed NAT for parasites (Trypanosoma cruzi, Babesia spp., Plasmodium spp.).
Conclusion:
This survey captures current use of blood donation NAT globally. There has been increased NAT usage over the last decade. It is clear that NAT contributes to improving blood transfusion safety globally; however, there is a need to overcome economic barriers for regions/countries not performing NAT.
Details
- Title
- International review of blood donation nucleic acid amplification testing
- Authors
- Helen M. Faddy (Corresponding Author) - University of the Sunshine Coast, Queensland, School of Health - BiomedicineCarla Osiowy - Public Health Agency of CanadaBrian Custer - VitalantMichael Busch - VitalantSusan L. Stramer - American Red CrossOpeyemi Adesina - Babcock UniversityThijs van de Laar - SanquinWai-Chiu Tsoi - Hong Kong Red CrossClaire Styles - Australian Red Cross LifebloodPhil Kiely - Australian Red Cross LifebloodAngelo Margaritis - Australian Red Cross LifebloodSo-Yong Kwon - Korean Red CrossYan Qiu - Beijing Red Cross Blood CenterXuelian Deng - Dalian Blood Centre (China, Dalian)Antoine Lewin - Hema Quebec, Med Affairs & Innovat, St Laurent, PQ, CanadaSigne Winther Jorgensen - Aarhus University HospitalChristian Erikstrup - Aarhus University HospitalDavid Juhl - University Hospital Schleswig-HolsteinSilvia Sauleda - Banc de Sang i TeixitsBernardo Armando Camacho Rodriguez - Institute of Biotechnology Science and Health Innovation (Columbia)Lisbeth Jennifer Catherine Soto Coral - Institute of Biotechnology Science and Health Innovation (Columbia)Paula Andrea Gaviria Garcia - Institute of Biotechnology Science and Health Innovation (Columbia)Sineenart Oota - Thai Red Cross SocietySheila F. O'Brien - Canadian Blood ServicesSilvano Wendel - Hospital Sírio-LibanêsEmma Castro - Generalitat ValencianaLaura Navarro Perez - Generalitat ValencianaHeli Harvala - NHS Blood and TransplantKaty Davison - NHS Blood and TransplantClaire Reynolds - NHS Blood and TransplantLisa Jarvis - Scottish National Blood Transfusion ServicePiotr Grabarczyk - Instytut Hematologii i TransfuzjologiAneta Kopacz - Instytut Hematologii i TransfuzjologiMagdalena Łętowska - Instytut Hematologii i TransfuzjologiNiamh O'Flaherty - Irish Blood Transfusion ServiceFiona Young - Irish Blood Transfusion ServicePadraig Williams - Irish Blood Transfusion ServiceLisa Burke - Irish Blood Transfusion ServiceSze Sze Chua - Health Sciences AuthorityAn Muylaert - Rode Kruis-VlaanderenIsabel Page - Centro Regional de HemodonaciónAnn Jones - Welsh Blood Service (Wales, Pontyclun)Christoph Niederhauser - Swiss Red CrossMarion Vermeulen - South African National Blood ServiceSyria Laperche - Établissement Français du SangPierre Gallian - Établissement Français du SangSalam Sawadogo - National Blood Transfusion Centre of Burkina Faso (Burkina Faso, Ouagadougou)Masahiro Satake - Japanese Red Cross Society, JapanAhmad Gharehbaghian - Shahid Beheshti University of Medical SciencesMarcelo Addas-Carvalho - Universidade Estadual de Campinas (UNICAMP)Sebastian Blanco - Central Blood Bank Foundation (Argentina)Sandra V. Gallego - Central Blood Bank Foundation (Argentina)Axel Seltsam - German Red CrossMarijke Weber-Schehl - German Red CrossArwa Z. Al-Riyami - Sultan Qaboos University HospitalKhuloud Al Maamari - Sultan Qaboos University HospitalFatma Ba Alawi - Sultan Qaboos University HospitalHem Chandra Pandey - All India Institute of Medical SciencesDora Mbanya - National Blood Transfusion Service (Cameroon, Yaoundé)Rochele Azevedo Franca - Fundação Pró-Sangue Hemocentro de São PauloRichard Charlewood - New Zealand Blood Service (New Zealand, Auckland)Virology and Surveillance; Risk Assessment and Policy subgroups of the ISBT Working Party on Transfusion-transmitted Infectious Diseases
- Publication details
- Vox Sanguinis, Vol.119(4), pp.315-325
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2024
- DOI
- 10.1111/vox.13592
- ISSN
- 1423-0410; 0042-9007
- PMID
- 38390819
- Copyright note
- © 2024 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Data Availability
- The data that support the findings of this study are available from the corresponding author upon reasonable request.
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991008895802621
- Output Type
- Journal article
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