Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors

Morgan J. Farley; Alexander N. Boytar; Kirsten N. Adlard; Chloe E. Salisbury; Nicolas H. Hart; Mia A. Schaumberg; David G. Jenkins; Tina L. Skinner

doi:10.1113/JP286043

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Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors

Journal article

Open access

Peer reviewed

Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors

Morgan J. Farley, Alexander N. Boytar, Kirsten N. Adlard, Chloe E. Salisbury, Nicolas H. Hart, Mia A. Schaumberg, David G. Jenkins and Tina L. Skinner

The Journal of Physiology, Vol.602(20), pp.5203-5215

2024

DOI: https://doi.org/10.1113/JP286043

PMID: 39303144

Appears in Cancer Research Cluster Research Collection

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Abstract

exercise

high-intensity interval training

immunology

interleukins

myokines

neoplasm

Pre-clinical murine and in vitro models have demonstrated that exercise suppresses tumour and cancer cell growth. These anti-oncogenic effects of exercise were associated with the exercise-mediated release of myokines such as interleukin (IL)-15. However, no study has quantified the acute IL-15 response in human cancer survivors, and whether physiological adaptations to exercise training (i.e. body composition and cardiorespiratory fitness) influence this response. In the present study breast, prostate and colorectal cancer survivors (n = 14) completed a single bout of high-intensity interval exercise (HIIE) [4×4 min at 85–95% heart rate (HR) peak, 3 min at 50–70% HR peak] before and after 7 months of three times weekly high-intensity interval training (HIIT) on a cycle ergometer. At each time point venous blood was sampled before and immediately after HIIE to assess the acute myokine (IL-15, IL-6, IL-10, IL-1ra) responses. Markers of inflammation, cardiorespiratory fitness and measures of body composition were obtained at baseline and 7 months. An acute bout of HIIE resulted in a significant increase in IL-15 concentrations (pre-intervention: 113%; P = 0.013, post-intervention: 102%; P = 0.005). Post-exercise IL-15 concentrations were associated with all other post-exercise myokine concentrations, lean mass (P = 0.031), visceral adipose tissue (P = 0.039) and absolute peak (P = 0.032). There was no significant effect of 7 months of HIIT on pre- or post-HIIE IL-15 concentrations (P > 0.05). This study demonstrates HIIE is a sufficient stimulus to increase circulating IL-15 and other myokines including IL-6, IL-10 and IL-1ra which may be clinically relevant in the anti-oncogenic effect of exercise and repetitive exposure to these effects may contribute to the positive relationship between exercise and cancer recurrence.

Details

Title: Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors
Authors: Morgan J. Farley (Corresponding Author) - The University of Queensland
Alexander N. Boytar - The University of Queensland
Kirsten N. Adlard - The University of Queensland
Chloe E. Salisbury - The University of Queensland
Nicolas H. Hart - University of Technology Sydney
Mia A. Schaumberg - University of the Sunshine Coast, Queensland, School of Health - Biomedicine
David G. Jenkins - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise Science
Tina L. Skinner - University of the Sunshine Coast, Queensland, School of Health
Publication details: The Journal of Physiology, Vol.602(20), pp.5203-5215
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2024
DOI: 10.1113/JP286043
ISSN: 1469-7793
PMID: 39303144
Copyright note: © 2024 The Author(s). The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Data Availability: The data are available from the authors on request.
Grants: Peer support in maintaining physical activity and health following an exercise training intervention for cancer survivors: A randomised controlled trial, 1132361, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: Tour de Cure (TDC). Grant Number: RSP-284-FY2023; CCA | Cancer Council Queensland (CCQ). Grant Number: N/A.
Organisation Unit: School of Health - Biomedicine; Healthy Ageing Research Cluster; School of Health; Cancer Research Cluster
Language: English
Record Identifier: 991066896402621
Output Type: Journal article

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