Files and links (1)
The Journal of Physiology - 2024 - Farley - Interleukin‐15 and high‐intensity exercise relationship with inflammation 786.92 kB
Published VersionCC BY V4.0, Open Access
Journal article
Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors
The Journal of Physiology, Vol.602(20), pp.5203-5215
2024
PMID: 39303144
Appears in Cancer Research Cluster Research Collection
Abstract
Pre-clinical murine and in vitro models have demonstrated that exercise suppresses tumour and cancer cell growth. These anti-oncogenic effects of exercise were associated with the exercise-mediated release of myokines such as interleukin (IL)-15. However, no study has quantified the acute IL-15 response in human cancer survivors, and whether physiological adaptations to exercise training (i.e. body composition and cardiorespiratory fitness) influence this response. In the present study breast, prostate and colorectal cancer survivors (n = 14) completed a single bout of high-intensity interval exercise (HIIE) [4×4 min at 85–95% heart rate (HR) peak, 3 min at 50–70% HR peak] before and after 7 months of three times weekly high-intensity interval training (HIIT) on a cycle ergometer. At each time point venous blood was sampled before and immediately after HIIE to assess the acute myokine (IL-15, IL-6, IL-10, IL-1ra) responses. Markers of inflammation, cardiorespiratory fitness and measures of body composition were obtained at baseline and 7 months. An acute bout of HIIE resulted in a significant increase in IL-15 concentrations (pre-intervention: 113%; P = 0.013, post-intervention: 102%; P = 0.005). Post-exercise IL-15 concentrations were associated with all other post-exercise myokine concentrations, lean mass (P = 0.031), visceral adipose tissue (P = 0.039) and absolute
peak (P = 0.032). There was no significant effect of 7 months of HIIT on pre- or post-HIIE IL-15 concentrations (P > 0.05). This study demonstrates HIIE is a sufficient stimulus to increase circulating IL-15 and other myokines including IL-6, IL-10 and IL-1ra which may be clinically relevant in the anti-oncogenic effect of exercise and repetitive exposure to these effects may contribute to the positive relationship between exercise and cancer recurrence.
Details
- Title
- Interleukin-15 and high-intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors
- Authors
- Morgan J. Farley (Corresponding Author) - The University of QueenslandAlexander N. Boytar - The University of QueenslandKirsten N. Adlard - The University of QueenslandChloe E. Salisbury - The University of QueenslandNicolas H. Hart - University of Technology SydneyMia A. Schaumberg - University of the Sunshine Coast, Queensland, School of Health - BiomedicineDavid G. Jenkins - University of the Sunshine Coast, Queensland, School of Health - Sports & Exercise ScienceTina L. Skinner - University of the Sunshine Coast, Queensland, School of Health
- Publication details
- The Journal of Physiology, Vol.602(20), pp.5203-5215
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2024
- DOI
- 10.1113/JP286043
- ISSN
- 1469-7793; 0022-3751
- PMID
- 39303144
- Copyright note
- © 2024 The Author(s). The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Data Availability
- The data are available from the authors on request.
- Grant note
- Tour de Cure (TDC). Grant Number: RSP-284-FY2023; CCA | Cancer Council Queensland (CCQ). Grant Number: N/A.
- Organisation Unit
- School of Health - Biomedicine; Healthy Ageing Research Cluster; School of Health; Cancer Research Cluster
- Language
- English
- Record Identifier
- 991066896402621
- Output Type
- Journal article
Metrics
24 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Neurosciences
- Physiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites