Logo image
Back
Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort
Journal article   Peer reviewed

Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort

L Tozzi, Lisa Garczarek, Deborah Janowitz, Dan J Stein, Katharina Wittfeld, Henrik Dobrowolny, Jim Lagopoulos, Sean N Hatton, Ian B Hickie, Angela Carballedo, …
Psychological Medicine, Vol.50(6), pp.1020-1031
2020
DOI: https://doi.org/10.1017/S003329171900093X
Appears in  Thompson Institute Research Collection
url
https://doi.org/10.1017/S003329171900093XView
Published Version

Abstract

childhood maltreatment ENIGMA cortical thickness major depressive disorder Other Collaborations Thompson Institute Special Collection UniSC Diversity Area - Disability and Inclusion UniSC Diversity Area - Life Stages
BACKGROUND: Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and how they interact with sex and age. METHODS: Within the ENIGMA-MDD network, severity and subtypes of CM using the Childhood Trauma Questionnaire were assessed and structural magnetic resonance imaging data from patients with MDD and healthy controls were analyzed in a mega-analysis comprising a total of 3872 participants aged between 13 and 89 years. Cortical thickness and surface area were extracted at each site using FreeSurfer. RESULTS: CM severity was associated with reduced cortical thickness in the banks of the superior temporal sulcus and supramarginal gyrus as well as with reduced surface area of the middle temporal lobe. Participants reporting both childhood neglect and abuse had a lower cortical thickness in the inferior parietal lobe, middle temporal lobe, and precuneus compared to participants not exposed to CM. In males only, regardless of diagnosis, CM severity was associated with higher cortical thickness of the rostral anterior cingulate cortex. Finally, a significant interaction between CM and age in predicting thickness was seen across several prefrontal, temporal, and temporo-parietal regions. CONCLUSIONS: Severity and type of CM may impact cortical thickness and surface area. Importantly, CM may influence age-dependent brain maturation, particularly in regions related to the default mode network, perception, and theory of mind.

Details

Metrics

2 File views/ downloads
815 Record Views
77 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
International collaboration
Web Of Science research areas
Psychiatry
Psychology
Psychology, Clinical

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being
#5 Gender Equality

Source: InCites

Logo image