Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont

Sharon R Longford; Alexandra H Campbell; Shaun Nielsen; Rebecca J Case; Staffan Kjelleberg; Peter D Steinberg

doi:10.1038/s41598-018-37062-z

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Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont

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Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont

Sharon R Longford, Alexandra H Campbell, Shaun Nielsen, Rebecca J Case, Staffan Kjelleberg and Peter D Steinberg

Scientific Reports, Vol.9(1), 1363

2019

DOI: https://doi.org/10.1038/s41598-018-37062-z

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Abstract

Our understanding of diseases has been transformed by the realisation that people are holobionts, comprised of a host and its associated microbiome(s). Disease can also have devastating effects on populations of marine organisms, including dominant habitat formers such as seaweed holobionts. However, we know very little about how interactions between microorganisms within microbiomes - of humans or marine organisms - affect host health and there is no underpinning theoretical framework for exploring this. We applied ecological models of succession to bacterial communities to understand how interactions within a seaweed microbiome affect the host. We observed succession of surface microbiomes on the red seaweed Delisea pulchra in situ, following a disturbance, with communities 'recovering' to resemble undisturbed states after only 12 days. Further, if this recovery was perturbed, a bleaching disease previously described for this seaweed developed. Early successional strains of bacteria protected the host from colonisation by a pathogenic, later successional strain. Host chemical defences also prevented disease, such that within-microbiome interactions were most important when the host's chemical defences were inhibited. This is the first experimental evidence that interactions within microbiomes have important implications for host health and disease in a dominant marine habitat-forming organism.

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Title: Interactions within the microbiome alter microbial interactions with host chemical defences and affect disease in a marine holobiont
Authors: Sharon R Longford (Author) - University of New South Wales
Alexandra H Campbell (Author) - University of the Sunshine Coast - School of Health & Sports Sciences
Shaun Nielsen (Author) - University of New South Wales
Rebecca J Case (Author) - University of Alberta, Canada
Staffan Kjelleberg (Author) - University of New South Wales
Peter D Steinberg (Author) - University of New South Wales
Publication details: Scientific Reports, Vol.9(1), 1363
Publisher: Nature Publishing Group
Date published: 2019
DOI: 10.1038/s41598-018-37062-z
ISSN: 2045-2322
Copyright note: Copyright © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451379002621
Output Type: Journal article