Journal article
Interaction Between DRD2 C957T Polymorphism and An Acute Psychosocial Stressor on Reward-Related Behavioral Impulsivity
Behavior Genetics, Vol.39(3), pp.285-295
2009
PMID: 19148742
Abstract
The dopamine D2 receptor (DRD2) C957T polymorphism CC genotype is associated with decreased striatal binding of DRD2 and executive function and working memory impairments in healthy adults. We investigated the relationships between C957T and acute stress with behavioral phenotypes of impulsivity in 72 young adults randomly allocated to either an acute psychosocial stress or relaxation induction condition. Homozygotes for 957C showed increased reward responsiveness after stress induction. They were also quicker when making immediate choices on the delay discounting task when stressed, compared with homozygotes who were not stressed. No effects were found for response inhibition, a dimension of impulsivity not related to extrinsic rewards. These data suggest that C957T is associated with a reward-related impulsivity endophenotype in response to acute psychosocial stress. Future studies should examine whether the greater sensitivity of 957C homozygotes to the effects of stress is mediated through dopamine release.
Details
- Title
- Interaction Between DRD2 C957T Polymorphism and An Acute Psychosocial Stressor on Reward-Related Behavioral Impulsivity
- Authors
- Melanie White (Author) - Queensland University of TechnologyBruce Lawford (Author) - Queensland University of TechnologyC Morris (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of Technology
- Publication details
- Behavior Genetics, Vol.39(3), pp.285-295
- Publisher
- Springer New York LLC
- Date published
- 2009
- DOI
- 10.1007/s10519-008-9255-7
- ISSN
- 1573-3297; 0001-8244
- PMID
- 19148742
- Copyright note
- Copyright (C) 2009. The author accepted version is reproduced here in accordance with the publisher's copyright policy. The final definitive version is available at: http://dx.doi.org/10.1007/s10519-008-9255-7
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550994302621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Behavioral Sciences
- Genetics & Heredity
- Psychology, Multidisciplinary
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