Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions

M R Davies; T N Tran; David J McMillan; D L Gardiner; B J Currie; K S Sriprakash

doi:10.1016/j.micinf.2005.03.018

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Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions

Journal article

Peer reviewed

Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions

M R Davies, T N Tran, David J McMillan, D L Gardiner, B J Currie and K S Sriprakash

Microbes and Infection, Vol.7(9-10), pp.1128-1138

2005

DOI: https://doi.org/10.1016/j.micinf.2005.03.018

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Abstract

Microbiology

Immunology

Medical Microbiology

streptococcus dysgalactiae

streptococcus pyogenes

streptococcus agalactiae

horizontal gene transfer

mobile genetic elements

streptococcal phages

group G streptococcus

Streptococcus dysgalactiae subsp. equisimilis (human group G streptococcus, GGS) is generally regarded as a commensal organism but can cause a spectrum of human diseases very similar to that caused by S. pyogenes (group A streptococcus, GAS). Lateral acquisition of genes between these two phylogenetically closely related species is well documented. However, the extent and mechanisms of lateral acquisitions is not known. We report here genomic subtraction between a pathogenic GGS isolate and a community GGS isolate and analyses of the gene sequences unique to the pathovar. Our results show that cross-species genetic transfers are common between GGS and two closely related human pathogens, GAS and the group B streptococcus. We also demonstrate that mobile genetic elements, such as phages and transposons, play an important role in the ongoing inter-species transfers of genetic traits between extant organisms in the community. Furthermore, lateral gene transfers between GAS and GGS may occur more frequently in geographical regions of high GAS endemicity. These observations may have important implications in understanding the epidemiology of streptococcal diseases in such regions.

Details

Title: Inter-species genetic movement may blur the epidemiology of streptococcal diseases in endemic regions
Authors: M R Davies (Author) - Queensland Institute of Medical Research
T N Tran (Author) - Queensland Institute of Medical Research
David J McMillan (Author) - Queensland Institute of Medical Research
D L Gardiner (Author) - Queensland Institute of Medical Research
B J Currie (Author) - Charles Darwin University
K S Sriprakash (Author) - Charles Darwin University
Publication details: Microbes and Infection, Vol.7(9-10), pp.1128-1138
Publisher: Elsevier Masson
Date published: 2005
DOI: 10.1016/j.micinf.2005.03.018
ISSN: 1286-4579
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450264702621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Immunology; Infectious Diseases; Microbiology

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