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Published VersionCC BY V4.0, Open Access
Journal article
Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis
Nature Communications, Vol.15, pp.1-14
2024
PMID: 38480728
Abstract
Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes. More than 75% of core genes are shared between the two species with one third demonstrating evidence of cross-species recombination. Twenty-five percent of mobile genetic element (MGE) clusters and 16 of 55 SDSE MGE insertion regions were shared across species. Assessing potential cross-protection from leading S. pyogenes vaccine candidates on SDSE, 12/34 preclinical vaccine antigen genes were shown to be present in >99% of isolates of both species. Relevant to possible vaccine evasion, six vaccine candidate genes demonstrated evidence of inter-species recombination. These findings demonstrate previously unappreciated levels of genomic overlap between these closely related pathogens with implications for streptococcal pathobiology, disease surveillance and prevention.
Details
- Title
- Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis
- Authors
- Ouli Xie - Peter Doherty InstituteJacqueline M Morris - Peter Doherty InstituteAndrew J Hayes - Peter Doherty InstituteRebecca J Towers - Charles Darwin UniversityMagnus G Jespersen - Peter Doherty InstituteJohn A Lees - European Bioinformatics InstituteNouri L Ben Zakour - The University of QueenslandOlga Berking - The University of QueenslandSarah L Baines - Peter Doherty InstituteGlen P Carter - Peter Doherty InstituteGerry Tonkin-Hill - University of OsloLayla Schrieber - The University of SydneyLiam McIntyre - Peter Doherty InstituteJake A Lacey - Peter Doherty InstituteTaylah B James - Peter Doherty InstituteKadaba S Sriprakash - University of New EnglandScott A Beatson - The University of QueenslandTadao Hasegawa - Nagoya City UniversityPhil Giffard - Charles Darwin UniversityAndrew C Steer - Murdoch Children's Research InstituteMichael R Batzloff - Institute for Glycomics, Griffith University, Southport, AustraliaBernard W Beall - Respiratory Disease Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USAMarcos D Pinho - University of LisbonMario Ramirez - University of LisbonDebra E Bessen - Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY, USAGordon Dougan - Wellcome Sanger InstituteStephen D Bentley - Parasites and Microbes, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UKMark J Walker - Institute for Molecular Bioscience, The University of Queensland, Brisbane, AustraliaBart J Currie - Charles Darwin UniversitySteven Y C Tong - Peter Doherty InstituteDavid J McMillan - University of the Sunshine Coast, Queensland, Centre for BioinnovationMark R Davies (Corresponding Author) - Peter Doherty Institute
- Publication details
- Nature Communications, Vol.15, pp.1-14
- Publisher
- Nature Publishing Group
- Date published
- 2024
- DOI
- 10.1038/s41467-024-46530-2
- ISSN
- 2041-1723
- PMID
- 38480728
- Copyright note
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/.
- Grants
- Grant note
- Avant Foundation Doctors in Training Research Scholarship (2021/000017) / The Wellcome Trust, UK / University of Melbourne CR Roper Fellowship
- Organisation Unit
- School of Science, Technology and Engineering; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 991014498202621
- Output Type
- Journal article
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