Journal article
Intensity Matters: High-intensity Interval Exercise Enhances Motor Cortex Plasticity More Than Moderate Exercise
Cerebral Cortex, Vol.30(1), pp.101-112
2020
PMID: 31041988
Abstract
A single bout of cardiovascular exercise can enhance plasticity in human cortex; however, the intensity required for optimal enhancement is debated. We investigated the effect of exercise intensity on motor cortex synaptic plasticity, using transcranial magnetic stimulation. Twenty healthy adults (Mage = 35.10 ± 13.25 years) completed three sessions. Measures of cortico-motor excitability (CME) and inhibition were obtained before and after a 20-min bout of either high-intensity interval exercise, moderate-intensity continuous exercise, or rest, and again after intermittent theta burst stimulation (iTBS). Results showed that high-intensity interval exercise enhanced iTBS plasticity more than rest, evidenced by increased CME and intracortical facilitation, and reduced intracortical inhibition. In comparison, the effect of moderate-intensity exercise was intermediate between high-intensity exercise and rest. Importantly, analysis of each participant’s plasticity response profile indicated that high-intensity exercise increased the likelihood of a facilitatory response to iTBS. We also established that the brain-derived neurotrophic factor Val66Met polymorphism attenuated plasticity responses following high-intensity exercise. These findings suggest that high-intensity interval exercise should be considered not only when planning exercise interventions designed to enhance neuroplasticity, but also to maximize the therapeutic potential of non-invasive brain stimulation. Additionally, genetic profiling may enhance efficacy of exercise interventions for brain health.
Details
- Title
- Intensity Matters: High-intensity Interval Exercise Enhances Motor Cortex Plasticity More Than Moderate Exercise
- Authors
- Sophie C Andrews (Corresponding Author) - Monash UniversityDylan Curtin (Author) - Monash UniversityZiarih Hawi (Author) - Monash UniversityJaeger Wongtrakun (Author) - Monash UniversityJulie C Stout (Author) - Monash UniversityJames P Coxon (Author) - Monash University
- Publication details
- Cerebral Cortex, Vol.30(1), pp.101-112
- Publisher
- Oxford University Press
- DOI
- 10.1093/cercor/bhz075
- ISSN
- 1460-2199
- PMID
- 31041988
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99659597502621
- Output Type
- Journal article
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- Neurosciences
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