Journal article
Integrative analysis of common genes and driver mutations implicated in hormone stimulation for four cancers in women
PeerJ, Vol.7, e6872
2019
Abstract
Cancer is one of the leading cause of death of women worldwide, and breast, ovarian, endometrial and cervical cancers contribute significantly to this every year. Developing early genetic-based diagnostic tools may be an effective approach to increase the chances of survival and provide more treatment opportunities. However, the current cancer genetic studies are mainly conducted independently and, hence lack of common driver genes involved in cancers in women. To explore the potential common molecular mechanism, we integrated four comprehensive literature-based databases to explore the shared implicated genetic effects. Using a total of 460 endometrial, 2,068 ovarian, 2,308 breast and 537 cervical cancer-implicated genes, we identified 52 genes which are common in all four types of cancers in women. Furthermore, we defined their potential functional role in endogenous hormonal regulation pathways within the context of four cancers in women. For example, these genes are strongly associated with hormonal stimulation, which may facilitate rapid diagnosis and treatment management decision making. Additional mutational analyses on combined the cancer genome atlas datasets consisting of 5,919 gynaecological and breast tumor samples were conducted to identify the frequently mutated genes across cancer types. For those common implicated genes for hormonal stimulants, we found that three quarter of 5,919 samples had genomic alteration with the highest frequency in MYC (22%), followed by NDRG1 (19%), ERBB2 (14%), PTEN (13%), PTGS2 (13%) and CDH1 (11%). We also identified 38 hormone related genes, eight of which are associated with the ovulation cycle. Further systems biology approach of the shared genes identified 20 novel genes, of which 12 were involved in the hormone regulation in these four cancers in women. Identification of common driver genes for hormone stimulation provided an unique angle of involving the potential of the hormone stimulants-related genes for cancer diagnosis and prognosis.
Details
- Title
- Integrative analysis of common genes and driver mutations implicated in hormone stimulation for four cancers in women
- Authors
- Salma Bhyan (Author) - University of the Sunshine CoastYong Kiat Wee (Author) - University of the Sunshine CoastYining Liu (Author) - Guangzhou Medical University, ChinaScott F Cummins (Author) - University of the Sunshine CoastMin Zhao (Author) - University of the Sunshine Coast
- Publication details
- PeerJ, Vol.7, e6872
- Publisher
- PeerJ, Ltd.
- Date published
- 2019
- DOI
- 10.7717/peerj.6872
- ISSN
- 2167-8359
- Copyright note
- Copyright © 2019 Bhyan et al. Distributed under Creative Commons CC-BY 4.0
- Organisation Unit
- School of Health - Biomedicine; School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; Library Services; School of Science, Technology and Engineering; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99451457102621
- Output Type
- Journal article
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- Oncology
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