Integrating objective gene-brain-behavior markers of psychiatric disorders

E Gordon; Belinda J Liddell; K J Brown; R Bryant; C Richard Clark; P Das; C Dobson-Stone; E Falconer; K Felmingham; G Flynn; J M Gatt; A Harris; Daniel F Hermens; P J Hopkinson; A H Kemp; S A Kuan; I Lazzaro; J Moyle; R H Paul; C J Rennie; P Schofield; T Whitford; L M Williams

doi:10.1142/S0219635207001465

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Integrating objective gene-brain-behavior markers of psychiatric disorders

Journal article

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Integrating objective gene-brain-behavior markers of psychiatric disorders

E Gordon, Belinda J Liddell, K J Brown, R Bryant, C Richard Clark, P Das, C Dobson-Stone, E Falconer, K Felmingham, G Flynn, …

Journal of Integrative Neuroscience, Vol.6(1), pp.1-34

2007

DOI: https://doi.org/10.1142/S0219635207001465

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Abstract

integrative neuroscience

markers

genetic

genomic

neuroimaging

EEG/ERPs

MRI

fMRI autonomic

general and social cognition

psychiatric disorders

There is little consensus about which objective markers should be used to assess major psychiatric disorders, and predict/evaluate treatment response for these disorders. Clinical practice relies instead on subjective signs and symptoms, such that there is a "translational gap" between research findings and clinical practice. This gap arises from: a) a lack of integrative theoretical models which provide a basis for understanding links between gene-brain-behavior mechanisms and clinical entities; b) the reliance on studying one measure at a time so that linkages between markers are their specificity are not established; and c) the lack of a definitive understanding of what constitutes normative function. Here, we draw on a standardized methodology for acquiring multiple sources of genomic, brain and behavioral data in the same subjects, to propose candidate markers of selected psychiatric disorders: depression, post-traumatic stress disorder, schizophrenia, attention-deficit/hyperactivity disorder and dementia disorders. This methodology has been used to establish a standardized international database which provides a comprehensive framework and the basis for testing hypotheses derived from an integrative theoretical model of the brain. Using this normative base, we present preliminary findings for a number of disorders in relation to the proposed markers. Establishing these objective markers will be the first step towards determining their sensitivity, specificity and treatment prediction in individual patients. © 2007 Imperial College Press.

Details

Title: Integrating objective gene-brain-behavior markers of psychiatric disorders
Authors: E Gordon (Author) - Brain Resource Company
Belinda J Liddell (Author) - Brain Resource Company
K J Brown (Author) - University of Sydney
R Bryant (Author) - University of New South Wales
C Richard Clark (Author) - Flinders University
P Das (Author) - University of Sydney
C Dobson-Stone (Author) - University of New South Wales
E Falconer (Author) - University of New South Wales
K Felmingham (Author) - University of Sydney
G Flynn (Author) - Liverpool Hospital
J M Gatt (Author) - University of Sydney
A Harris (Author) - University of Sydney
Daniel F Hermens (Author) - University of Sydney
P J Hopkinson (Author) - University of Sydney
A H Kemp (Author) - University of Sydney
S A Kuan (Author) - University of Sydney
I Lazzaro (Author) - University of Sydney
J Moyle (Author) - Brain Resource Company
R H Paul (Author) - University of Missouri, United States
C J Rennie (Author) - University of Sydney
P Schofield (Author) - University of New South Wales
T Whitford (Author) - University of Sydney
L M Williams (Author) - University of Sydney
Publication details: Journal of Integrative Neuroscience, Vol.6(1), pp.1-34
Publisher: IOS Press
Date published: 2007
DOI: 10.1142/S0219635207001465
ISSN: 0219-6352
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451046202621
Output Type: Journal article

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