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Psychiatry Clin Neurosci - 2023 - Can - Insights into the Neurobiology of Suicidality Explicating the role of3.66 MB
Accepted Version Embargoed Access, Embargo ends: 16-Jun-2025
Journal article
Insights into the Neurobiology of Suicidality: Explicating the role of glutamatergic systems through the lens of ketamine
Psychiatry and Clinical Neurosciences, Vol.77(10), pp.513-529
2023
PMID: 37329495
Abstract
Suicidality is a prevalent mental health condition, and managing suicidal patients is one of the most challenging tasks for healthcare professionals due to the lack of rapid-acting, effective psychopharmacological treatment options. According to the literature, suicide has neurobiological underpinnings that are not fully understood, and current treatments for suicidal tendencies have considerable limitations. To treat suicidality and prevent suicide, new treatments are required; to achieve this, the neurobiological processes underlying suicidal behaviour must be thoroughly investigated. Although multiple neurotransmitter systems, particularly serotonergic systems, have been studied in the past, less has been reported in relation to disruptions in glutamatergic neurotransmission, neuronal plasticity and neurogenesis that result from stress-related abnormalities of the hypothalamic-pituitary-adrenal (HPA) system. Informed by the literature which reports robust anti-suicidal and anti-depressive properties of subanaesthetic doses of ketamine, this review aims to provide an examination of the neurobiology of suicidality (and relevant mood disorders) with implications of pertinent animal, clinical and post-mortem studies. We discuss dysfunctions in the glutamatergic system, which may play a role in the neuropathology of suicidality and the role of ketamine in restoring synaptic connectivity at the molecular levels.
Details
- Title
- Insights into the Neurobiology of Suicidality: Explicating the role of glutamatergic systems through the lens of ketamine
- Authors
- Adem Can (Corresponding Author)Jules Mitchell (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMegan Dutton (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteMaxwell Bennett (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteDaniel Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJim Lagopoulos (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
- Publication details
- Psychiatry and Clinical Neurosciences, Vol.77(10), pp.513-529
- Publisher
- John Wiley & Sons, Inc.
- DOI
- 10.1111/pcn.13572
- ISSN
- 1440-1819
- PMID
- 37329495
- Copyright note
- This is the peer reviewed version of the following article: Can, A.T., Mitchell, J.S., Dutton, M., Bennett, M., Hermens, D.F. and Lagopoulos, J. (2023), Insights into the Neurobiology of Suicidality: Explicating the role of glutamatergic systems through the lens of ketamine. Psychiatry Clin. Neurosci.. Accepted Author Manuscript. https://doi.org/10.1111/pcn.13572, which has been published in final form at https://doi.org/10.1111/pcn.13572. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
- Organisation Unit
- Thompson Institute; University of the Sunshine Coast, Queensland; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99735295802621
- Output Type
- Journal article
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- Clinical Neurology
- Neurosciences
- Psychiatry
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