Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

S J Cozzi; Steven Ogbourne; C James; H G Rebel; F R de Gruijl; B Ferguson; J Gardner; Thuy T Lee; T Larcher; A Suhrbier

doi:10.1038/jid.2011.418

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Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

Journal article

Peer reviewed

Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

S J Cozzi, Steven Ogbourne, C James, H G Rebel, F R de Gruijl, B Ferguson, J Gardner, Thuy T Lee, T Larcher and A Suhrbier

Journal of Investigative Dermatology, Vol.132(4), pp.1263-1271

2012

DOI: https://doi.org/10.1038/jid.2011.418

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Abstract

skin cancer

UV exposure

ingenol mebutate

Skin cancer is the most prevalent cancer worldwide and is primarily caused by chronic UV exposure. Here, we describe the topical field-directed treatment of SKH1/hr mice with UVB-damaged skin with ingenol mebutate, a new topical drug shown to be effective for the treatment of actinic keratosis (AK). Application of 0.05% ingenol mebutate gel to photo-damaged skin resulted in a E70% reduction in the number of skin lesions that subsequently emerged compared with placebo treatment. Ingenol mebutate treatment also reduced the number of mutant p53 keratinocyte patches by E70%. The treatment resulted in epidermal cell death, acute inflammation, recruitment of neutrophils, hemorrhage, and eschar formation, all of which resolved over several weeks. Ingenol mebutate field-directed treatment might thus find utility in the removal of subclinical precancerous cells from UV-damaged skin. Field-directed treatment may be particularly suitable for patients who have AKs surrounded by UV-damaged skin.

Details

Title: Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches
Authors: S J Cozzi (Author) - Queensland Institute of Medical Research
Steven Ogbourne (Author) - Peplin Ltd, Brisbane
C James (Author) - Queensland Institute of Medical Research
H G Rebel (Author) - Leiden University Medical Center, Netherlands
F R de Gruijl (Author) - Leiden University Medical Center, Netherlands
B Ferguson (Author) - Queensland Institute of Medical Research
J Gardner (Author) - Queensland Institute of Medical Research
Thuy T Lee (Author) - Queensland Institute of Medical Research
T Larcher (Author) - Ecole Nationale Ve´te´rinaire Nantes, France
A Suhrbier (Author) - Queensland Institute of Medical Research
Publication details: Journal of Investigative Dermatology, Vol.132(4), pp.1263-1271
Publisher: Nature Publishing Group
Date published: 2012
DOI: 10.1038/jid.2011.418
ISSN: 0022-202X
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449768602621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Dermatology

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