Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

S J Cozzi; Steven Ogbourne; C James; H G Rebel; F R de Gruijl; B Ferguson; J Gardner; Thuy T Lee; T Larcher; A Suhrbier

doi:10.1038/jid.2011.418

Back

Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

Journal article

Peer reviewed

Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches

S J Cozzi, Steven Ogbourne, C James, H G Rebel, F R de Gruijl, B Ferguson, J Gardner, Thuy T Lee, T Larcher and A Suhrbier

Journal of Investigative Dermatology, Vol.132(4), pp.1263-1271

2012

DOI: https://doi.org/10.1038/jid.2011.418

Files and links (1)

url

https://doi.org/10.1038/jid.2011.418View

Published Version

Abstract

skin cancer

UV exposure

ingenol mebutate

Skin cancer is the most prevalent cancer worldwide and is primarily caused by chronic UV exposure. Here, we describe the topical field-directed treatment of SKH1/hr mice with UVB-damaged skin with ingenol mebutate, a new topical drug shown to be effective for the treatment of actinic keratosis (AK). Application of 0.05% ingenol mebutate gel to photo-damaged skin resulted in a E70% reduction in the number of skin lesions that subsequently emerged compared with placebo treatment. Ingenol mebutate treatment also reduced the number of mutant p53 keratinocyte patches by E70%. The treatment resulted in epidermal cell death, acute inflammation, recruitment of neutrophils, hemorrhage, and eschar formation, all of which resolved over several weeks. Ingenol mebutate field-directed treatment might thus find utility in the removal of subclinical precancerous cells from UV-damaged skin. Field-directed treatment may be particularly suitable for patients who have AKs surrounded by UV-damaged skin.

Details

Title: Ingenol Mebutate Field-Directed Treatment of UVB-Damaged Skin Reduces Lesion Formation and Removes Mutant p53 Patches
Authors: S J Cozzi (Author) - Queensland Institute of Medical Research
Steven Ogbourne (Author) - Peplin Ltd, Brisbane
C James (Author) - Queensland Institute of Medical Research
H G Rebel (Author) - Leiden University Medical Center, Netherlands
F R de Gruijl (Author) - Leiden University Medical Center, Netherlands
B Ferguson (Author) - Queensland Institute of Medical Research
J Gardner (Author) - Queensland Institute of Medical Research
Thuy T Lee (Author) - Queensland Institute of Medical Research
T Larcher (Author) - Ecole Nationale Ve´te´rinaire Nantes, France
A Suhrbier (Author) - Queensland Institute of Medical Research
Publication details: Journal of Investigative Dermatology, Vol.132(4), pp.1263-1271
Publisher: Nature Publishing Group
DOI: 10.1038/jid.2011.418
ISSN: 0022-202X
Organisation Unit: School of Science, Technology and Engineering; School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449768602621
Output Type: Journal article

Metrics

4 File views/ downloads

637 Record Views

58 Times Cited - Web of Science

See more details

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Dermatology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites