Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles

Vahid Ebrahiminejad; Atefeh Malek-khatabi; Zahra Faraji Rad

doi:10.1002/admt.202301272

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Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles

Journal article

Open access

Peer reviewed

Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles

Vahid Ebrahiminejad, Atefeh Malek-khatabi and Zahra Faraji Rad

Advanced Materials Technologies, Vol.9(4), pp.1-16

2024

DOI: https://doi.org/10.1002/admt.202301272

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Abstract

dissolving microneedles

drug delivery

insertion force

low-frequency vibration

skin strain

Microneedles (MNs) offer a promising solution for increasing the effectiveness of transdermal drug delivery and diagnostics. However, challenges such as large-scale manufacturing, partial MN penetration, and uncontrolled drug delivery limit the effectiveness of the technology. To overcome these challenges, current research examines the effects of skin strain and vibration on MN insertion and drug delivery. A novel multifeatured impact applicator are developed for improving skin insertion that features a combination of skin stretching, eccentric rotating mass (ERM), and linear resonant actuator (LRA) micro-vibration capabilities. In addition, a scalable replication method for dissolving microneedle patches (DMNPs) are developed using two-photon polymerization (TPP) and soft embossing processes. The DMNPs are used to evaluate the diffusion and concentration of a model drug, fluorescein sodium salt (FSS), when applied using ERM and LRA micro-vibration at different frequencies. Additionally, a new computer simulation method is presented to model the MN insertion into the multilayered hyperelastic skin model, incorporating skin strain and vibrational effects. The results indicate that applying skin strain and vibration decreases the force required for MN insertion and enhances the dissolution and diffusion depth of the drug in the skin, which can enhance the drug permeability and effectiveness of MN devices.

Details

Title: Influence of Low-Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles
Authors: Vahid Ebrahiminejad - University of Southern Queensland
Atefeh Malek-khatabi - Tehran University of Medical Sciences
Zahra Faraji Rad (Corresponding Author) - University of Southern Queensland
Publication details: Advanced Materials Technologies, Vol.9(4), pp.1-16
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
Date published: 2024
DOI: 10.1002/admt.202301272
ISSN: 2365-709X
Copyright note: © 2024 The Authors. Advanced Materials Technologies published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Data Availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 991140405102621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Materials Science, Multidisciplinary

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