Induced Refractive Error Changes the Optical Coherence Tomography Angiography Transverse Magnification and Vascular Indices

Barsha Lal; David Alonso-Caneiro; Scott A Read; Andrew Carkeet

doi:10.1016/j.ajo.2021.04.012

$Induced Refractive Error Changes the Optical Coherence Tomography Angiography Transverse Magnification and Vascular Indices$

Journal article

Peer reviewed

Induced Refractive Error Changes the Optical Coherence Tomography Angiography Transverse Magnification and Vascular Indices

Barsha Lal, David Alonso-Caneiro, Scott A Read and Andrew Carkeet

American Journal of Ophthalmology, Vol.229, pp.230-241

2021

DOI: https://doi.org/10.1016/j.ajo.2021.04.012

PMID: 33905748

Abstract

Purpose: To assess the effect of changing anterior eye refractive power with contact lenses on the transverse magnification of en face images and associated vascular indices from optical coherence tomographic angiography (OCT-A). Design: Prospective crossover study. Methods: Spherical soft contact lenses (–6 diopter [D] to +6 D in 2 D steps) were used to induce anterior eye refractive power changes in 11 healthy young adults and 3 × 3-mm macular scans were captured using OCT-A (Zeiss AngioPlex, software version 11.0; Cirrus HD-OCT 5000, Carl Zeiss Meditec Inc). Image transverse magnification was predicted based on refraction and biometry measurements and compared with empirical changes in the en face images measured with image analysis. Linear regression analysis was performed to assess the relationship between induced refractive ametropia and foveal avascular zone (FAZ) area, perimeter, circularity, and vessel density and perfusion density. Results: The predicted transverse magnification was linearly related to induced refractive ametropia and to the empirical transverse magnification changes (average slope: 1.02, 95% CI: 0.90-1.34). All the OCT-A indices showed linear relationships with induced refractive ametropia (P < .05) with the 12 D tested range altering the indices by 7% to 12%. After correcting for transverse magnification, all OCT-A indices except FAZ area were linearly related to induced refractive ametropia (P < .05) and were reduced to 1% to 9%. Conclusions: This study is the first to show that induced refractive ametropia can affect OCT-A image magnification and indices. These changes are clinically important and need to be considered along with biometry effects when interpreting OCT-A indices. Transverse magnification changes can affect the ability of OCT-A to precisely measure linear dimensions of blood vessels.

Details

Title: Induced Refractive Error Changes the Optical Coherence Tomography Angiography Transverse Magnification and Vascular Indices
Authors: Barsha Lal (Corresponding Author) - Queensland University of Technology
David Alonso-Caneiro (Author) - Queensland University of Technology
Scott A Read (Author) - Queensland University of Technology
Andrew Carkeet (Author) - Queensland University of Technology
Publication details: American Journal of Ophthalmology, Vol.229, pp.230-241
Publisher: Elsevier Inc.
DOI: 10.1016/j.ajo.2021.04.012
ISSN: 1879-1891
PMID: 33905748
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99973598502621
Output Type: Journal article