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Internal Medicine Journal - 2024 - Commins - Indications and outcomes of transjugular intrahepatic portosystemic shunt690.38 kB
Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Indications and outcomes of transjugular intrahepatic portosystemic shunt insertion in two regional Australian hepatology centres
Internal Medicine Journal, Vol.54(8), pp.1302-1309
2024
PMID: 38654627
Appears in UniSC Supported Open Access Outputs
Abstract
Background
Transjugular intrahepatic portosystemic shunt (TIPS) is an important therapy for complications of portal hypertension but remains underutilised in regional settings.
Aims
The aim of this study is to explore the demographics, indications, outcomes and complications in patients undergoing TIPS in two regional hepatology centres.
Methods
Retrospective analysis was undertaken of all patients undergoing TIPS at two regional centres between January 2017 and March 2023. The primary outcome measures were efficacy and complications of TIPS. Patient demographics (such as age, baseline liver severity scores and aetiology of liver disease) and indications for TIPS are detailed.
Results
Forty-eight patients underwent TIPS. Median age was 56 years (interquartile range (IQR): 46–65). The most common indications for TIPS were refractory ascites (n = 17) and failure of secondary prophylaxis of variceal bleeding (n = 13). Cumulative survival at 3 months and 1 year was 93% and 77% respectively. There was no significant difference in outcomes based on TIPS indication. The median number of paracenteses in patients undergoing TIPS for refractory ascites 1 year pre- and post-TIPS were 10 (IQR: 4.5–16) and 2 (IQR: 0–4) respectively (P < 0.001). There were no procedure-related deaths. Inpatient management of liver disease complications had a mean cost of $32 874.67 (SEM: 7779) in 1 year pre-TIPS compared with $12 304.70 (SEM: 3531.1) in 1 year post-TIPS (P < 0.001).
Conclusions
TIPS is a safe and effective treatment to reduce complications of portal hypertension and can be performed successfully in the regional setting.
Details
- Title
- Indications and outcomes of transjugular intrahepatic portosystemic shunt insertion in two regional Australian hepatology centres
- Authors
- Natalie Commins (Corresponding Author) - Sunshine Coast University HospitalDeloshaan Subhaharan - Sunshine Coast University HospitalRajiv Kurup - Sunshine Coast University HospitalTehara Wickremeratne - Sunshine Coast University HospitalJonathan Mitchell - Sunshine Coast University HospitalJulie Elmes - Gold Coast HospitalAlicia Braund - Gold Coast HospitalNatalie Funakoshi - Gold Coast HospitalJonathan Langton - Sunshine Coast University HospitalPaul Leschke - Sunshine Coast University HospitalJames O'Beirne - University of the Sunshine Coast
- Publication details
- Internal Medicine Journal, Vol.54(8), pp.1302-1309
- Publisher
- John Wiley & Sons, Inc.
- Date published
- 2024
- DOI
- 10.1111/imj.16384
- ISSN
- 1445-5994
- PMID
- 38654627
- Copyright note
- © 2024 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 991024895002621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Gastroenterology & Hepatology
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