Journal article
Increased platelet-derived microparticles in the coronary circulation of percutaneous transluminal coronary angioplasty patients
Blood Coagulation and Fibrinolysis, Vol.15(6), pp.475-482
2004
Abstract
Platelet-derived microparticles that are produced during platelet activation are capable of adhesion and aggregation. Endothelial trauma that occurs during percutaneous transluminal coronary angioplasty (PTCA) may support platelet-derived microparticle adhesion and contribute to development of restenosis. We have previously reported an increase in platelet-derived microparticles in peripheral arterial blood with angioplasty. This finding raised concerns regarding the role of platelet-derived microparticles in restenosis, and therefore the aim of this study was to monitor levels in the coronary circulation. The study population consisted of 19 angioplasty patients. Paired coronary artery and sinus samples were obtained following heparinization, following contrast administration, and subsequent to all vessel manipulation. Platelet-derived microparticles were identified with an anti-CD61 (glycoprotein IIIa) fluorescence-conjugated antibody using flow cytometry. There was a significant decrease in arterial platelet-derived microparticles from heparinization to contrast administration (P = 0.001), followed by a significant increase to the end of angioplasty (P = 0.004). However, there was no significant change throughout the venous samples. These results indicate that the higher level of platelet-derived microparticles after angioplasty in arterial blood remained in the coronary circulation. Interestingly, levels of thrombin-antithrombin complexes did not rise during PTCA. This may have implications for the development of coronary restenosis post-PTCA, although this remains to be determined. © 2004 Lippincott Williams & Wilkins.
Details
- Title
- Increased platelet-derived microparticles in the coronary circulation of percutaneous transluminal coronary angioplasty patients
- Authors
- Judy A Craft (Author) - Queensland University of TechnologyP P Masci (Author) - University of QueenslandM S Roberts (Author) - University of QueenslandT A Brighton (Author) - Princess Alexandra HospitalP Garrahy (Author) - Princess Alexandra HospitalS Cox (Author) - Princess Alexandra HospitalN A Marsh (Author) - Queensland University of Technology
- Publication details
- Blood Coagulation and Fibrinolysis, Vol.15(6), pp.475-482
- Publisher
- Lippincott Williams & Wilkins
- Date published
- 2004
- DOI
- 10.1097/00001721-200408000-00006
- ISSN
- 0957-5235; 0957-5235
- Organisation Unit
- School of Health - Nursing; University of the Sunshine Coast, Queensland; School of Nursing, Midwifery and Paramedicine - Legacy
- Language
- English
- Record Identifier
- 99451479502621
- Output Type
- Journal article
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