Increased neurotropic threat from burkholderia pseudomallei strains with a b. Mallei–like variation in the bima motility gene, Australia

J L Morris; A Fane; Derek S Sarovich; Erin P Price; C M Rush; B L Govan; E Parker; M Mayo; B J Currie; N Ketheesan

doi:10.3201/eid2305.151417

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Increased neurotropic threat from burkholderia pseudomallei strains with a b. Mallei–like variation in the bima motility gene, Australia

Journal article

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Increased neurotropic threat from burkholderia pseudomallei strains with a b. Mallei–like variation in the bima motility gene, Australia

J L Morris, A Fane, Derek S Sarovich, Erin P Price, C M Rush, B L Govan, E Parker, M Mayo, B J Currie and N Ketheesan

Emerging Infectious Diseases, Vol.23(5), pp.740-749

2017

DOI: https://doi.org/10.3201/eid2305.151417

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Abstract

Neurologic melioidosis is a serious, potentially fatal form of Burkholderia pseudomallei infection. Recently, we reported that a subset of clinical isolates of B. pseudomallei from Australia have heightened virulence and potential for dissemination to the central nervous system. In this study, we demonstrate that this subset has a B. mallei-like sequence variation of the actin-based motility gene, bimA. Compared with B. pseudomallei isolates having typical bimA alleles, isolates that contain the B. mallei-like variation demonstrate increased persistence in phagocytic cells and increased virulence with rapid systemic dissemination and replication within multiple tissues, including the brain and spinal cord, in an experimental model. These findings highlight the implications of bimA variation on disease progression of B. pseudomallei infection and have considerable clinical and public health implications with respect to the degree of neurotropic threat posed to human health. © 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.

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Title: Increased neurotropic threat from burkholderia pseudomallei strains with a b. Mallei–like variation in the bima motility gene, Australia
Authors: J L Morris (Author) - James Cook University
A Fane (Author) - James Cook University
Derek S Sarovich (Author) - Menzies School of Health Research
Erin P Price (Author) - Menzies School of Health Research
C M Rush (Author) - James Cook University
B L Govan (Author) - James Cook University
E Parker (Author) - James Cook University
M Mayo (Author) - Menzies School of Health Research
B J Currie (Author) - Menzies School of Health Research
N Ketheesan (Author) - James Cook University
Publication details: Emerging Infectious Diseases, Vol.23(5), pp.740-749
Publisher: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention
Date published: 2017
DOI: 10.3201/eid2305.151417
ISSN: 1080-6040
Organisation Unit: University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450589902621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Immunology; Infectious Diseases

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